Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders

被引：40

作者：

Roberts, Timothy P. L. ^{[1
]}

Schmidt, Gwen L. ^{[1
]}

Egeth, Marc ^{[1
]}

Blaskey, Lisa ^{[1
,2
]}

Rey, Michael M. ^{[1
]}

Edgar, J. Christopher ^{[1
]}

Levy, Susan E. ^{[2
]}

机构：

[1] Childrens Hosp Philadelphia, Dept Radiol, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

来源：

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY | 2008年 / 68卷 / 02期

关键词：

autism spectrum disorder; magnetoencephalography; language impairment; auditory;

D O I：

10.1016/j.ijpsycho.2008.01.012

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

While magnetoencephalography (MEG) is of increasing utility in the assessment of pediatric patients with seizure disorders, this reflects only a part of the clinical potential of the technology. Beyond epilepsy, a broad range of developmental psychiatric disorders require the spatial and temporal resolution of brain activity offered by MEG. This article reviews the application of MEG in the study of auditory processing as an aspect of language impairment in children. Specifically, the potential application of MEG is elaborated in autism spectrum disorders (ASD), a devastating disorder with prevalence of I in 150. Results demonstrate the sensitivity of MEG for detection of abnormalities of auditory processing in ASD ('electrophysiological signatures') and their clinical correlates. These findings offer promise for the comprehensive assessment of developmental neuropsychiatric disorders. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：149 / 160

页数：12

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