Effect of reducing portion size at a compulsory meal on later energy intake, gut hormones, and appetite in overweight adults

被引:33
作者
Lewis, Hannah B. [1 ]
Ahern, Amy L. [1 ]
Solis-Trapala, Ivonne [1 ]
Walker, Celia G. [1 ]
Reimann, Frank [2 ]
Gribble, Fiona M. [2 ]
Jebb, Susan A. [1 ]
机构
[1] Med Res Council Human Nutr Res, Diet & Obes Res, Cambridge, England
[2] Univ Cambridge, Inst Metab Sci, Dept Clin Biochem, Cambridge CB2 1TN, England
基金
英国医学研究理事会;
关键词
PEPTIDE YY; FOOD-INTAKE; OBESE SUBJECTS; BODY-WEIGHT; SATIETY; GHRELIN; INSULIN; GLUCOSE; CARBOHYDRATE; WOMEN;
D O I
10.1002/oby.21105
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
ObjectiveLarger portion sizes (PS) are associated with greater energy intake (EI), but little evidence exists on the appetitive effects of PS reduction. This study investigated the impact of reducing breakfast PS on subsequent EI, postprandial gastrointestinal hormone responses, and appetite ratings. MethodsIn a randomized crossover design (n=33 adults; mean BMI 29 kg/m(2)), a compulsory breakfast was based on 25% of gender-specific estimated daily energy requirements; PS was reduced by 20% and 40%. EI was measured at an ad libitum lunch (240 min) and snack (360 min) and by weighed diet diaries until bed. Blood was sampled until lunch in 20 participants. Appetite ratings were measured using visual analogue scales. ResultsEI at lunch (control: 2,930203; 20% reduction: 2,853 +/- 198; 40% reduction: 2,911 +/- 179 kJ) and over the whole day except breakfast (control: 7,374 +/- 361; 20% reduction: 7,566 +/- 468; 40% reduction: 7,413 +/- 417 kJ) did not differ. Postprandial PYY, GLP-1, GIP, insulin, and fullness profiles were lower and hunger, desire to eat, and prospective consumption higher following 40% reduction compared to control. Appetite ratings profiles, but not hormone concentrations, were associated with subsequent EI. ConclusionsSmaller portions at breakfast led to reductions in gastrointestinal hormone secretion but did not affect subsequent energy intake, suggesting small reductions in portion size may be a useful strategy to constrain EI.
引用
收藏
页码:1362 / 1370
页数:9
相关论文
共 40 条
  • [1] Inhibition of food intake in obese subjects by peptide YY3-36
    Batterham, RL
    Cohen, MA
    Ellis, SM
    Le Roux, CW
    Withers, DJ
    Frost, GS
    Ghatei, MA
    Bloom, SR
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (10) : 941 - 948
  • [2] Blom WAM, 2005, AM J CLIN NUTR, V81, P367
  • [3] Overconsumption and obesity: Peptides and susceptibility to weight gain
    Blundell, J. E.
    Levin, F.
    King, N. A.
    Barkeling, B.
    Gustafson, T.
    Hellstrom, P. M.
    Holst, J. J.
    Naslund, E.
    [J]. REGULATORY PEPTIDES, 2008, 149 (1-3) : 32 - 38
  • [4] Appetite Responds to Changes in Meal Content, Whereas Ghrelin, Leptin, and Insulin Track Changes in Energy Availability
    Borer, Katarina T.
    Wuorinen, Elizabeth
    Ku, Kimberly
    Burant, Charles
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (07) : 2290 - 2298
  • [5] Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men
    Brennan, Ixchel M.
    Luscombe-Marsh, Natalie D.
    Seimon, Radhika V.
    Otto, Baerbel
    Horowitz, Michael
    Wishart, Judith M.
    Feinle-Bisset, Christine
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 303 (01): : G129 - G140
  • [6] Colman AndrewM., 2009, Oxford Dictionary of Psychology
  • [7] Effects of weight and energy content of preloads on subsequent appetite and food intake
    DeGraaf, G
    Hulshof, T
    [J]. APPETITE, 1996, 26 (02) : 139 - 151
  • [8] Total peptide YY is a correlate of postprandial energy expenditure but not of appetite or energy intake in healthy women
    Doucet, Eric
    Laviolette, Manon
    Imbeault, Pascal
    Strychar, Irene
    Rabasa-Lhoret, Remi
    Prud'homme, Denis
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2008, 57 (10): : 1458 - 1464
  • [9] Appetite sensations and satiety quotient: Predictors of energy intake and weight loss
    Drapeau, Vicky
    King, Neil
    Hetherington, Marion
    Doucet, Eric
    Blundell, John
    Tremblay, Angelo
    [J]. APPETITE, 2007, 48 (02) : 159 - 166
  • [10] Fitt E, 2014, PUBLIC HEALTH NUTR, P1