Influence of New Promising Analgesic Compounds on Locomotor Activity of Mice

被引：0
作者：
Palikova, Yu. A. [1 ,3 ]
Skobtsova, L. A. [1 ,3 ]
Zharmukhamedova, T. Yu. [1 ]
Palikov, V. A. [1 ,3 ]
Rudenko, V. B. [1 ]
Khokhlova, O. N. [1 ,2 ]
Lobanov, A. V. [1 ,2 ]
Rzhevskii, D. I. [1 ,2 ]
Slashcheva, G. A. [1 ]
D'yachenko, E. V. [3 ]
Belous, G. I. [3 ]
Andreev, Ya. A. [4 ,5 ]
Logashina, Yu. A. [4 ,5 ]
Kozlov, S. A. [4 ]
Yavorskii, A. N. [3 ]
Elyakova, E. G. [4 ]
D'yachenko, I. A. [1 ,2 ,3 ]
机构：
[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Pushchino Branch, 6 Prospekt Nauki, Pushchino 142290, Moscow Oblast, Russia
[2] Russian Acad Sci, Pushchino Sci Ctr, 6 Prospekt Nauki, Pushchino 142290, Moscow Oblast, Russia
[3] Pushchino State Inst Nat Sci, 3 Prospekt Nauki, Pushchino 142290, Moscow Oblast, Russia
[4] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, 16-10 Miklukho Maklaya St, Moscow 117997, Russia
[5] IM Sechenov First Moscow State Med Univ, Inst Mol Med, 8 Trubetskaya St, Moscow 119991, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2018年 / 52卷 / 08期
关键词：
polypeptides; TRPV1; ASIC; and P2X3 receptors; locomotor activity; sedative effect; P2X3; RECEPTORS; SEA-ANEMONE; PEPTIDE; ASIC3;
D O I：
10.1007/s11094-018-1884-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The influence of new promising peptide (APCH3 and PT1) and nonpeptide analgesics (sevanol) on the behavior of male ICR mice was studied. All studied compounds at doses producing significant analgesic effects did not influence the behavior of mice in open-field tests. However, APCH at doses 10,000 times greater than the pharmacologically active dose produced sedative effects. Also, sevanol at a dose of 35 mg/kg caused statistically significant behavioral changes relative to the pharmacologically active dose (1 mg/kg) but not to the controls.
引用
收藏
页码：700 / 703
页数：4
相关论文
共 50 条
[31]   LIPOPOLYSACCHARIDE INDUCES FEVER AND DEPRESSES LOCOMOTOR-ACTIVITY IN UNRESTRAINED MICE [J].
KOZAK, W ;
CONN, CA ;
KLUGER, MJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (01) :R125-R135
[32]   Assessment of the developmental neurotoxicity of compounds by measuring locomotor activity in zebrafish embryos and larvae [J].
Selderslaghs, Ingrid W. T. ;
Hooyberghs, Jef ;
Blust, Ronny ;
Witters, Hilda E. .
NEUROTOXICOLOGY AND TERATOLOGY, 2013, 37 :44-56
[33]   Influence of light intensity on plasma melatonin and locomotor activity rhythms in tench [J].
Vera, LM ;
López-Olmeda, JF ;
Bayarri, MJ ;
Madrid, JA ;
Sánchez-Vázquez, FJ .
CHRONOBIOLOGY INTERNATIONAL, 2005, 22 (01) :67-78
[34]   Environmentally relevant concentrations of microplastics influence the locomotor activity of aquatic biota [J].
Sun, Tao ;
Zhan, Junfei ;
Li, Fei ;
Ji, Chenglong ;
Wu, Huifeng .
JOURNAL OF HAZARDOUS MATERIALS, 2021, 414
[35]   Assessing locomotor activity in larval zebrafish: Influence of extrinsic and intrinsic variables [J].
Padilla, S. ;
Hunter, D. L. ;
Padnos, B. ;
Frady, S. ;
MacPhail, R. C. .
NEUROTOXICOLOGY AND TERATOLOGY, 2011, 33 (06) :624-630
[36]   Influence of new monoterpene homologues of GABA on the central nervous system activity in mice [J].
Librowski, T ;
Czarnecki, R ;
Mendyk, A ;
Jastrzebska, M .
POLISH JOURNAL OF PHARMACOLOGY, 2000, 52 (04) :317-321
[37]   Effects of NMDA receptor blockers on cocaine-stimulated locomotor activity in mice [J].
Uzbay, IT ;
Wallis, CJ ;
Lal, H ;
Forster, MJ .
BEHAVIOURAL BRAIN RESEARCH, 2000, 108 (01) :57-61
[38]   Sildenafil enhances locomotor activity in young mice and exerts anxiogenic effects in both young and aged mice [J].
Demirci, Deniz ;
Mutlu, Oguz ;
Akar, Furuzan ;
Celikyurt, Ipek Komsuoglu ;
Ulak, Guner .
MEDICAL SCIENCE MONITOR BASIC RESEARCH, 2014, 20 :15-21
[39]   Effects of inhaled 1,1,1-trichloroethane on locomotor activity in mice [J].
Bowen, SE ;
Balster, RL .
NEUROTOXICOLOGY AND TERATOLOGY, 1996, 18 (01) :77-81
[40]   EFFECTS OF JURAK EXTRACT ON THE LOCOMOTOR-ACTIVITY AND BRAIN ACETYLCHOLINESTERASE LEVEL IN MICE [J].
AJAREM, JS ;
AHMED, M .
SAUDI MEDICAL JOURNAL, 1995, 16 (02) :156-160
12345