Influence of New Promising Analgesic Compounds on Locomotor Activity of Mice

被引：0

作者：

Palikova, Yu. A. ^{[1
,3
]}

Skobtsova, L. A. ^{[1
,3
]}

Zharmukhamedova, T. Yu. ^{[1
]}

Palikov, V. A. ^{[1
,3
]}

Rudenko, V. B. ^{[1
]}

Khokhlova, O. N. ^{[1
,2
]}

Lobanov, A. V. ^{[1
,2
]}

Rzhevskii, D. I. ^{[1
,2
]}

Slashcheva, G. A. ^{[1
]}

D'yachenko, E. V. ^{[3
]}

Belous, G. I. ^{[3
]}

Andreev, Ya. A. ^{[4
,5
]}

Logashina, Yu. A. ^{[4
,5
]}

Kozlov, S. A. ^{[4
]}

Yavorskii, A. N. ^{[3
]}

Elyakova, E. G. ^{[4
]}

D'yachenko, I. A. ^{[1
,2
,3
]}

机构：

[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Pushchino Branch, 6 Prospekt Nauki, Pushchino 142290, Moscow Oblast, Russia

[2] Russian Acad Sci, Pushchino Sci Ctr, 6 Prospekt Nauki, Pushchino 142290, Moscow Oblast, Russia

[3] Pushchino State Inst Nat Sci, 3 Prospekt Nauki, Pushchino 142290, Moscow Oblast, Russia

[4] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, 16-10 Miklukho Maklaya St, Moscow 117997, Russia

[5] IM Sechenov First Moscow State Med Univ, Inst Mol Med, 8 Trubetskaya St, Moscow 119991, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2018年 / 52卷 / 08期

关键词：

polypeptides; TRPV1; ASIC; and P2X3 receptors; locomotor activity; sedative effect; P2X3; RECEPTORS; SEA-ANEMONE; PEPTIDE; ASIC3;

D O I：

10.1007/s11094-018-1884-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The influence of new promising peptide (APCH3 and PT1) and nonpeptide analgesics (sevanol) on the behavior of male ICR mice was studied. All studied compounds at doses producing significant analgesic effects did not influence the behavior of mice in open-field tests. However, APCH at doses 10,000 times greater than the pharmacologically active dose produced sedative effects. Also, sevanol at a dose of 35 mg/kg caused statistically significant behavioral changes relative to the pharmacologically active dose (1 mg/kg) but not to the controls.

引用

页码：700 / 703

页数：4

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