Mouse Models of Psoriasis: A Comprehensive Review

被引：99

作者：

Gangwar, Roopesh Singh ^{[1
,2
]}

Gudjonsson, Johann E. ^{[3
]}

Ward, Nicole L. ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Dept Nutr, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Dept Dermatol, Cleveland, OH 44106 USA

[3] Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2022年 / 142卷 / 3 PT B期

关键词：

INDUCED SKIN INFLAMMATION; DELTA T-CELLS; NF-KAPPA-B; VASCULAR INFLAMMATION; GENE-EXPRESSION; TRANSGENIC MICE; UNINVOLVED SKIN; ANIMAL-MODEL; IMIQUIMOD; KERATINOCYTE;

D O I：

10.1016/j.jid.2021.06.019

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The use of preclinical animal models of psoriasis has significantly increased over the last three decades, with each model having unique strengths and limitations. Some models translate better to human disease, and many have provided unique insight into psoriasis disease pathogenesis. In this comprehensive review, we present a comparative description and discussion of genetic mouse models, xenograft approaches, and elicited methods using cytokine injections into and topical imiquimod onto mice. We provide an inclusive list of genetically modified animals that have had imiquimod applied to or cytokines injected into their skin and describe the outcomes of these manipulations. This review will provide a valuable resource for those interested in working with psoriasis animal models.

引用

页码：884 / 897

页数：14

共 107 条

[11] Biologic Treatments of Psoriasis: An Update for the Clinician [J].

Brownstone, Nicholas D. ;

Hong, Julie ;

Mosca, Megan ;

Hadeler, Edward ;

Liao, Wilson ;

Bhutani, Tina ;

Koo, John .

BIOLOGICS-TARGETS & THERAPY, 2021, 15 :39-51

[12] Polygenic mouse model of psoriasiform skin disease in CD18-deficient mice [J].

Bullard, DC ;

ScharffetterKochanek, K ;

McArthur, MJ ;

Chosay, JG ;

McBride, ME ;

Montgomery, CA ;

Beaudet, AL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (05) :2116-2121

[13] IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis [J].

Chan, Jason R. ;

Blumenschein, Wendy ;

Murphy, Erin ;

Diveu, Caroline ;

Wiekowski, Maria ;

Abbondanzo, Susan ;

Lucian, Linda ;

Geissler, Richard ;

Brodie, Scott ;

Kimball, Alexa B. ;

Gorman, Daniel M. ;

Smith, Kathleen ;

Malefyt, Rene de Waal ;

Kastelein, Robert A. ;

McClanahan, Terrill K. ;

Bowman, Edward P. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (12) :2577-2587

[14] The Adaptor Protein CIKS/Act1 Is Essential for IL-25-Mediated Allergic Airway Inflammation [J].

Claudio, Estefania ;

Sonder, Soren Ulrik ;

Saret, Sun ;

Carvalho, Gabrielle ;

Ramalingam, Thirumalai R. ;

Wynn, Thomas A. ;

Chariot, Alain ;

Garcia-Perganeda, Antonio ;

Leonardi, Antonio ;

Paun, Andrea ;

Chen, Amy ;

Ren, Nina Y. ;

Wang, Hongshan ;

Siebenlist, Ulrich .

JOURNAL OF IMMUNOLOGY, 2009, 182 (03) :1617-1630

[15] INTRODUCTION OF A RABBIT BETA-GLOBIN GENE INTO THE MOUSE GERM LINE [J].

COSTANTINI, F ;

LACY, E .

NATURE, 1981, 294 (5836) :92-94

[16] IL-6 Regulates Neutrophil Microabscess Formation in IL-17A-Driven Psoriasiform Lesions [J].

Croxford, Andrew L. ;

Karbach, Susanne ;

Kurschus, Florian C. ;

Woertge, Simone ;

Nikolaev, Alexei ;

Yogev, Nir ;

Klebow, Sabrina ;

Schueler, Rebecca ;

Reissig, Sonja ;

Piotrowski, Carolin ;

Brylla, Elke ;

Bechmann, Ingo ;

Scheller, Juregen ;

Rose-John, Stefan ;

Wunderlich, F. Thomas ;

Muenzel, Thomas ;

von Stebut, Esther ;

Waisman, Ari .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2014, 134 (03) :728-735

[17] Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice [J].

Detmar, M ;

Brown, LF ;

Schön, MP ;

Elicker, BM ;

Velasco, P ;

Richard, L ;

Fukumura, D ;

Monsky, W ;

Claffey, KP ;

Jain, RK .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 111 (01) :1-6

[18] Extracellular ATP and IL-23 Form a Local Inflammatory Circuit Leading to the Development of a Neutrophil-Dependent Psoriasiform Dermatitis [J].

Diaz-Perez, Julio A. ;

Killeen, Meaghan E. ;

Yang, Yin ;

Carey, Cara D. ;

Falo, Louis D. ;

Mathers, Alicia R. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2018, 138 (12) :2595-2605

[19] UNINVOLVED SKIN FROM PSORIATIC PATIENTS DEVELOPS SIGNS OF INVOLVED PSORIATIC SKIN AFTER BEING GRAFTED ONTO NUDE-MICE [J].

FRAKI, JE ;

BRIGGAMAN, RA ;

LAZARUS, GS .

SCIENCE, 1982, 215 (4533) :685-687

[20] TEMPORAL CONTROL OF GENE-EXPRESSION IN TRANSGENIC MICE BY A TETRACYCLINE-RESPONSIVE PROMOTER [J].

FURTH, PA ;

STONGE, L ;

BOGER, H ;

GRUSS, P ;

GOSSEN, M ;

KISTNER, A ;

BUJARD, H ;

HENNIGHAUSEN, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (20) :9302-9306

← 1 2 3 4 5 6 7 8 9 10 →