Mouse Models of Psoriasis: A Comprehensive Review

被引：99

作者：

Gangwar, Roopesh Singh ^{[1
,2
]}

Gudjonsson, Johann E. ^{[3
]}

Ward, Nicole L. ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Dept Nutr, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Dept Dermatol, Cleveland, OH 44106 USA

[3] Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2022年 / 142卷 / 3 PT B期

关键词：

INDUCED SKIN INFLAMMATION; DELTA T-CELLS; NF-KAPPA-B; VASCULAR INFLAMMATION; GENE-EXPRESSION; TRANSGENIC MICE; UNINVOLVED SKIN; ANIMAL-MODEL; IMIQUIMOD; KERATINOCYTE;

D O I：

10.1016/j.jid.2021.06.019

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The use of preclinical animal models of psoriasis has significantly increased over the last three decades, with each model having unique strengths and limitations. Some models translate better to human disease, and many have provided unique insight into psoriasis disease pathogenesis. In this comprehensive review, we present a comparative description and discussion of genetic mouse models, xenograft approaches, and elicited methods using cytokine injections into and topical imiquimod onto mice. We provide an inclusive list of genetically modified animals that have had imiquimod applied to or cytokines injected into their skin and describe the outcomes of these manipulations. This review will provide a valuable resource for those interested in working with psoriasis animal models.

引用

页码：884 / 897

页数：14

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