Role of angiotensin in the rostral ventrolateral medulla in the development and maintenance of hypertension

被引：23
作者：
Allen, Andrew M. [1 ,2 ]
机构：
[1] Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia
[2] Univ Melbourne, Florey Neurosci Inst, Melbourne, Vic 3010, Australia
来源：
CURRENT OPINION IN PHARMACOLOGY | 2011年 / 11卷 / 02期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
SYMPATHETIC-NERVE ACTIVITY; BLOOD-PRESSURE; NEURAL MECHANISMS; AT(1) RECEPTORS; NADPH OXIDASE; BULBOSPINAL NEURONS; EMOTIONAL-STRESS; GENE-EXPRESSION; II RECEPTOR; BRAIN-STEM;
D O I：
10.1016/j.coph.2010.12.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Whilst crucial for behavioural and homeostatic responses to environmental challenges, chronic elevation of sympathetic nervous system activity to specific vascular beds is associated with hypertension. Indeed such elevated activity may drive the increase in blood pressure seen in some people and in some experimental models of hypertension. This review discusses the neural circuitry involved in generating and modulating sympathetic efferent nerve activity, focusing on the premotor neurons of the rostral ventrolateral medulla. Neurons in the rostral ventrolateral medulla show altered responses to angiotensin II in experimental models of hypertension, suggesting that this might be an important node for interaction between these two systems that are crucial for regulation of blood pressure.
引用
收藏
页码：117 / 123
页数：7
相关论文
共 66 条
[1]   Photostimulation of channelrhodopsin-2 expressing ventrolateral medullary neurons increases sympathetic nerve activity and blood pressure in rats [J].
Abbott, Stephen B. G. ;
Stornetta, Ruth L. ;
Socolovsky, Carmela S. ;
West, Gavin H. ;
Guyenet, Patrice G. .
JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (23) :5613-5631
[2]   Excess Dietary Salt Alters Angiotensinergic Regulation of Neurons in the Rostral Ventrolateral Medulla [J].
Adams, Julye M. ;
McCarthy, John J. ;
Stocker, Sean D. .
HYPERTENSION, 2008, 52 (05) :932-U533
[3]   Gene knockout of insulin-regulated aminopeptidase: Loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory [J].
Albiston, Anthony L. ;
Fernando, Ruani N. ;
Yeatman, Holly R. ;
Burns, Peta ;
Ng, Leelee ;
Daswani, Dina ;
Diwakarla, Shanti ;
Pham, Vi ;
Chai, Siew Yeen .
NEUROBIOLOGY OF LEARNING AND MEMORY, 2010, 93 (01) :19-30
[4]   ROLE OF THE SPINAL-CORD IN GENERATING THE 2-HZ TO 6-HZ RHYTHM IN RAT SYMPATHETIC OUTFLOW [J].
ALLEN, AM ;
ADAMS, JM ;
GUYENET, PG .
AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (05) :R938-R945
[5]   Central Neural Regulation of Cardiovascular Function by Angiotensin: A Focus on the Rostral Ventrolateral Medulla [J].
Allen, Andrew M. ;
O'Callaghan, E. L. ;
Chen, D. ;
Bassi, J. K. .
NEUROENDOCRINOLOGY, 2009, 89 (04) :361-369
[6]   Transient AT1 receptor-inhibition in prehypertensive spontaneously hypertensive rats results in maintained cardiac protection until advanced age [J].
Baumann, Marcus ;
Janssen, Ben J. A. ;
Hermans, J. J. Rob ;
Peutz-Kootstra, Canne ;
Witzke, Oliver ;
Smits, Jos F. M. ;
Boudier, Harry A. J. Struijker .
JOURNAL OF HYPERTENSION, 2007, 25 (01) :207-215
[7]   AT1 angiotensin II receptor and novel non-AT1, non-AT2 angiotensin II/III binding site in brainstem cardiovascular regulatory centers of the spontaneously hypertensive rat [J].
Bourassa, Erick A. ;
Fang, Xiefan ;
Li, Xia ;
Sved, Alan F. ;
Speth, Robert C. .
BRAIN RESEARCH, 2010, 1359 :98-106
[8]   Dietary salt enhances angiotensin-II-induced superoxide formation in the rostral ventrolateral medulla [J].
Braga, Valdir A. .
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2010, 155 (1-2) :14-18
[9]   ANGIOTENSIN PEPTIDES IN SPONTANEOUSLY HYPERTENSIVE AND NORMOTENSIVE DONRYU RATS [J].
CAMPBELL, DJ ;
DUNCAN, AM ;
KLADIS, A ;
HARRAP, SB .
HYPERTENSION, 1995, 25 (05) :928-934
[10]   ELECTROPHYSIOLOGICAL PROPERTIES OF NEURONS IN THE ROSTRAL VENTROLATERAL MEDULLA OF NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS [J].
CHAN, RKW ;
CHAN, YS ;
WONG, TM .
BRAIN RESEARCH, 1991, 549 (01) :118-126
1234567