Role of Activin A in the Induction of Foxp3+ and Foxp3- CD4+ Regulatory T Cells

被引:1
作者
Huber, Samuel [1 ,2 ]
Schramm, Christoph [2 ]
机构
[1] Yale Univ, Dept Immunobiol, Sch Med, New Haven, CT 06520 USA
[2] Univ Klinikum Hamburg Eppendorf, Med Klin 1, D-20246 Hamburg, Germany
关键词
regulatory T cells; cytokines; immune regulation; tolerance; GROWTH-FACTOR-BETA; BONE MORPHOGENETIC PROTEINS; MARROW STROMAL FIBROBLASTS; TRANSCRIPTION FACTOR FOXP3; TGF-BETA; CUTTING EDGE; IN-VIVO; INFLAMMATORY RESPONSE; THYMOCYTE DEVELOPMENT; MAST-CELLS;
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Regulatory T cells (Tregs) play a crucial role in the maintenance of immune homeostasis. The two best studied types of CD4(+) regulatory T cells are the Foxp3(+) Tregs and the T regulatory type 1 (Tr1) cells. CD4(+) regulatory T cells play a protective role in autoimmune disease. On the other hand, they also may have pathogenic properties in infectious diseases and carcinogenesis. Because of their potential for the therapy of various human diseases, factors responsible for expanding regulatory T cells are of interest. One of these factors, the TGFbeta family member activin A, is expressed in different inflammatory conditions, such as inflammatory bowel disease, rheumatoid arthritis, and asthma. Although activin A might have pro- and anti-inflammatory properties depending on the context of expression, this review focuses on the role of activin A for the expansion of the CD4(+) regulatory T-cell pool.
引用
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页码:53 / 60
页数:8
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