Serum uric acid and fatal myocardial infarction: detection of prognostic cut-off values: The URRAH (Uric Acid Right for Heart Health) study

被引：74

作者：

Casiglia, Edoardo ^{[1
]}

Tikhonoff, Valerie ^{[2
]}

Virdis, Agostino ^{[3
]}

Masi, Stefano ^{[3
]}

Barbagallo, Carlo M. ^{[4
]}

Bombelli, Michele ^{[5
]}

Bruno, Bernardino ^{[6
]}

Cicero, Arrigo F. G. ^{[7
]}

Cirillo, Massimo ^{[8
]}

Cirillo, Pietro ^{[9
]}

Desideri, Giovambattista ^{[6
]}

D'Elia, Lanfranco ^{[10
]}

Ferri, Claudio ^{[6
]}

Galletti, Ferruccio ^{[10
]}

Gesualdo, Loreto ^{[9
]}

Giannattasio, Cristina ^{[11
,12
]}

Iaccarino, Guido ^{[13
]}

Lippa, Luciano ^{[14
]}

Mallamaci, Francesca ^{[15
]}

Maloberti, Alessandro ^{[11
,12
]}

Mazza, Alberto ^{[16
]}

Muiesan, Maria Lorenza ^{[17
]}

Nazzaro, Pietro ^{[18
]}

Palatini, Paolo ^{[1
]}

Parati, Gianfranco ^{[19
,20
]}

Pontremoli, Roberto ^{[21
,22
]}

Quarti-Trevano, Fosca ^{[5
]}

Rattazzi, Marcello ^{[2
,23
]}

Rivasi, Giulia ^{[24
,25
]}

Salvetti, Massimo ^{[17
]}

Tocci, Giuliano ^{[26
,27
]}

Ungar, Andrea ^{[24
,25
]}

Verdecchia, Paolo ^{[28
]}

Viazzi, Francesca ^{[21
,22
]}

Volpe, Massimo ^{[26
,27
]}

Grassi, Guido ^{[5
]}

Borghi, Claudio ^{[7
]}

机构：

[1] Univ Padua, Studium Patavinum, Dept Med, Via Giustiniani 2,Via Vergerio 10, I-35128 Padua, Italy

[2] Univ Padua, Dept Med, Padua, Italy

[3] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

[4] Univ Palermo, Biomed Dept Internal Med & Specialist, Palermo, Italy

[5] Univ Milano Bicocca, Dept Med & Surg, Clin Med, Monza, Italy

[6] Univ Aquila, Dept Life Hlth & Environm Sci, Laquila, Italy

[7] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Bologna, Italy

[8] Federico II Univ Naples, Dept Publ Hlth, Naples, Italy

[9] Aldo Moro Univ Bari, Dept Emergency & Organ Transplantat, Nephrol Dialysis & Transplantat Unit, Bari, Italy

[10] Federico II Univ Naples, Dept Clin Med & Surg, Med Sch, Naples, Italy

[11] Osped Niguarda Ca Granda, ADe Gasperis Dept, Cardiol 4, Milan, Italy

[12] Milano Bicocca Univ, Sch Med & Surg, Milan, Italy

[13] Federico II Univ Naples, Dept Adv Biomed Sci, Naples, Italy

[14] Italian Soc Gen Med SIMG, Laquila, Italy

[15] CNR IFC, Clin Epidemiol Renal Dis & Hypertens, Reggio Cal Unit, Reggio Di Calabria, Italy

[16] Santa Maria Misericordia Gen Hosp, Dept Internal Med, AULSS 5 Polesana, Rovigo, Italy

[17] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy

[18] Univ Bari, Dept Med Basic Sci Neurosci & Sense Organs, Med Sch, Bari, Italy

[19] San Luca Hosp, Dept Cardiovasc Neural & Metab Sci, IRCCS, Ist Auxol Italiano, Milan, Italy

[20] Univ Milano Bicocca, Dept Med & Surg, Milan, Italy

[21] Univ Genoa, Dept Internal Med, Genoa, Italy

[22] Policlin San Martino, Genoa, Italy

[23] Ca Foncello Univ Hosp, Med Interna 1, Treviso, Italy

[24] Careggi Hosp, Dept Geriatr & Intens Care Med, Florence, Italy

[25] Univ Florence, Florence, Italy

[26] Univ Rome Sapienza, St Andrea Hosp, Fac Med & Psychol, Hypertens Unit,Div Cardiol,Dept Clin & Mol Med, Rome, Italy

[27] IRCCS Neuromed, Pozzilli, Italy

[28] Hosp S Maria Misericordia, Perugia, Italy

来源：

JOURNAL OF HYPERTENSION | 2020年 / 38卷 / 03期

关键词：

cut-off value; mortality; myocardial infarction; sex; uric acid; CARDIOVASCULAR-DISEASE; RISK; HYPERURICEMIA; MORTALITY; DEATH; WOMEN; MEN;

D O I：

10.1097/HJH.0000000000002287

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Objective: The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension conceived and designed an ad-hoc study aimed at searching for prognostic cut-off values of serum uric acid (SUA) in predicting fatal myocardial infaction (MI) in women and men. Methods: The URic acid Right for heArt Health study is a nationwide, multicentre, observational cohort study involving data on individuals aged 18-95 years recruited on a regional community basis from all the territory of Italy under the patronage of the Italian Society of Hypertension with a mean follow-up period of 122.3 +/- 66.9 months. Results: A total of 23 467 individuals were included in the analysis. Cut-off values of SUA able to discriminate MI status were identified by mean of receiver operating characteristic curves in the whole database (>5.70 mg/dl), in women (>5.26 mg/dl) and in men (>5.49 mg/dl). Multivariate Cox regression analyses adjusted for confounders (age, arterial hypertension, diabetes, chronic kidney disease, smoking habit, ethanol intake, BMI, haematocrit, LDL cholesterol and use of diuretics) identified an independent association between SUA and fatal MI in the whole database (hazard ratio 1.381, 95% confidence intervals, 1.096-1.758, P = 0.006) and in women (hazard ratio 1.514, confidence intervals 1.105-2.075, P < 0.01), but not in men. Conclusion: The results of the current study confirm that SUA is an independent risk factor for fatal MI after adjusting for potential confounding variables, and demonstrate that a prognostic cut-off value associated to fatal MI can be identified at least in women.

引用

页码：412 / 419

页数：8

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