MicroRNAs and cystic fibrosis - an epigenetic perspective

被引：24

作者：

Xu, Wenming ^{[1
,2
]}

Hui, Chen ^{[2
]}

Yu, Sidney Siu Bun ^{[2
]}

Jing, Chen ^{[2
]}

Chan, Hsiao Chang ^{[1
,2
]}

机构：

[1] Sichuan Univ, W China Univ Hosp 2, Inst Women & Childrens Hlth, SCU CUHK Joint Lab Reprod Med, Chengdu 610041, Peoples R China

[2] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Epithelial Cell Biol Res Ctr, Shatin, Hong Kong, Peoples R China

来源：

CELL BIOLOGY INTERNATIONAL | 2011年 / 35卷 / 05期

关键词：

CFTR; cystic fibrosis; epigenetic; microRNA; TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL-CELLS; BICARBONATE SECRETION; LUNG-DISEASE; CFTR; EXPRESSION; MUTATIONS; GENE; BIOLOGY; GENOTYPE;

D O I：

10.1042/CBI20100664

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CF (cystic fibrosis) is a recessive genetic disease caused by mutations of the CFTR (cystic fibrosis transmembrane conductance regulator), a cAMP-activated anion channel, exhibiting a multitude of clinical manifestations including lung inflammation/infection, pancreatic insufficiency/diabetes, intestinal obstruction and infertility in both sexes. While mutation DF508 is found in 70% of CF patients, large variation in disease phenotypes and severity is observed among the patients. This review discusses current theories accounting for the disease variations and puts forth an epigenetic hypothesis involving microRNAs.

引用

页码：463 / 466

页数：4

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