MicroRNAs and cystic fibrosis - an epigenetic perspective

被引：24

作者：

Xu, Wenming ^{[1
,2
]}

Hui, Chen ^{[2
]}

Yu, Sidney Siu Bun ^{[2
]}

Jing, Chen ^{[2
]}

Chan, Hsiao Chang ^{[1
,2
]}

机构：

[1] Sichuan Univ, W China Univ Hosp 2, Inst Women & Childrens Hlth, SCU CUHK Joint Lab Reprod Med, Chengdu 610041, Peoples R China

[2] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Epithelial Cell Biol Res Ctr, Shatin, Hong Kong, Peoples R China

来源：

CELL BIOLOGY INTERNATIONAL | 2011年 / 35卷 / 05期

关键词：

CFTR; cystic fibrosis; epigenetic; microRNA; TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL-CELLS; BICARBONATE SECRETION; LUNG-DISEASE; CFTR; EXPRESSION; MUTATIONS; GENE; BIOLOGY; GENOTYPE;

D O I：

10.1042/CBI20100664

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CF (cystic fibrosis) is a recessive genetic disease caused by mutations of the CFTR (cystic fibrosis transmembrane conductance regulator), a cAMP-activated anion channel, exhibiting a multitude of clinical manifestations including lung inflammation/infection, pancreatic insufficiency/diabetes, intestinal obstruction and infertility in both sexes. While mutation DF508 is found in 70% of CF patients, large variation in disease phenotypes and severity is observed among the patients. This review discusses current theories accounting for the disease variations and puts forth an epigenetic hypothesis involving microRNAs.

引用

页码：463 / 466

页数：4

共 30 条

[1] Oxidative Stress Causes IL8 Promoter Hyperacetylation in Cystic Fibrosis Airway Cell Models [J].

Bartling, Toni R. ;

Drumm, Mitchell L. .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2009, 40 (01) :58-65

[2] Genetic Modifiers Play a Substantial Role in Diabetes Complicating Cystic Fibrosis [J].

Blackman, Scott M. ;

Hsu, Stephanie ;

Vanscoy, Lori L. ;

Collaco, J. Michael ;

Ritter, Sarah E. ;

Naughton, Kathleen ;

Cutting, Garry R. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (04) :1302-1309

[3] Adult cystic fibrosis [J].

Boyle, Michael P. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (15) :1787-1793

[4] Interaction between a novel TGFB1 haplotype and CFTR genotype is associated with improved lung function in cystic fibrosis [J].

Bremer, Lindsay A. ;

Blackman, Scott M. ;

Vanscoy, Lori L. ;

McDougal, Kathryn E. ;

Bowers, Amanda ;

Naughton, Kathleen M. ;

Cutler, David J. ;

Cutting, Garry R. .

HUMAN MOLECULAR GENETICS, 2008, 17 (14) :2228-2237

[5] Molecular biology - The two faces of miRNA [J].

Buchan, J. Ross ;

Parker, Roy .

SCIENCE, 2007, 318 (5858) :1877-1878

[6] The cystic fibrosis transmembrane conductance regulator in reproductive health and disease [J].

Chan, Hsiao Chang ;

Ruan, Ye Chun ;

He, Qiong ;

Chen, Min Hui ;

Chen, Hui ;

Xu, Wen Ming ;

Chen, Wen Ying ;

Xie, Chen ;

Zhang, Xiao Hu ;

Zhou, Zhen .

JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (10) :2187-2195

[7] Cl- Is Required for HCO3- Entry Necessary for Sperm Capacitation in Guinea Pig: Involvement of a Cl-/HCO3- Exchanger (SLC26A3) and CFTR [J].

Chen, Wen Ying ;

Xu, Wen Ming ;

Chen, Zhang Hui ;

Ni, Ya ;

Yuan, Yu Ying ;

Zhou, Si Chang ;

Zhou, Wen Wei ;

Tsang, Lai Ling ;

Chung, Yiu Wa ;

Hoglund, Pia ;

Chan, Hsiao Chang ;

Shi, Qi Xian .

BIOLOGY OF REPRODUCTION, 2009, 80 (01) :115-123

[8] MUTATIONS IN THE CYSTIC-FIBROSIS GENE IN PATIENTS WITH CONGENITAL ABSENCE OF THE VAS-DEFERENS [J].

CHILLON, M ;

CASALS, T ;

MERCIER, B ;

BASSAS, L ;

LISSENS, W ;

SILBER, S ;

ROMEY, MC ;

RUIZROMERO, J ;

VERLINGUE, C ;

CLAUSTRES, M ;

NUNES, V ;

FEREC, C ;

ESTIVILL, X .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (22) :1475-1480

[9] Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis [J].

Choi, JY ;

Muallem, D ;

Kiselyov, K ;

Lee, MG ;

Thomas, PJ ;

Muallem, S .

NATURE, 2001, 410 (6824) :94-97

[10] Interactions between secondhand smoke and genes that affect cystic fibrosis lung disease [J].

Collaco, J. Michael ;

Vanscoy, Lori ;

Bremer, Lindsay ;

McDougal, Kathryn ;

Blackman, Scott M. ;

Bowers, Amanda ;

Naughton, Kathleen ;

Jennings, Jacky ;

Ellen, Jonathan ;

Cutting, Garry R. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (04) :417-424

← 1 2 3 →