Ribonucleotide reductase subunit M2 is a potential prognostic marker and therapeutic target for soft tissue sarcoma

被引：6

作者：

Das, Basudeb ^{[1
]}

Jain, Neha ^{[1
]}

Mallick, Bibekanand ^{[1
]}

机构：

[1] Natl Inst Technol, Dept Life Sci, RNAi & Funct Genom Lab, Rourkela 769008, Odisha, India

来源：

GENE | 2022年 / 808卷

关键词：

Cancer; RRM2; Metastasis; Oncogenesis; Soft Tissue Sarcoma; Therapeutic Target; CLINICAL-VALUE; PHASE-I; RRM2; CANCER; EXPRESSION; INHIBITOR; IDENTIFICATION; SENESCENCE; GENES;

D O I：

10.1016/j.gene.2021.145988

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Soft tissue sarcomas (STSs) are highly aggressive malignant tumors that exhibit poor therapeutic outcomes. Hence, we aimed to track down a potential gene that can be used as a prognostic marker and therapeutic target for this malignancy. We integrated omics analysis of clinical data and in vitro studies and identified Ribonucleotide reductase subunit M2 (RRM2) as a potential oncogene associated with STS prognosis. We found RRM2 is highly expressed in STS cell lines and tissues. STS patients with increased RRM2 levels showed worse overall survival, disease-free survival, progression-free survival, and disease-specific survival. Further, overexpression of RRM2 in HT1080 cells induces proliferation, migration, invasion, and colony formation, whereas its silencing arrest the cell cycle at G0/G1 phase and induces apoptosis. Taken together, we established RRM2 to be positively associated with oncogenesis and prognosis of STS and therefore could be a promising prognostic marker and therapeutic target.

引用

页数：14

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