Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3)

被引：44

作者：

Fanidi, Anouar ^{[1
]}

Muller, David C. ^{[1
,2
]}

Yuan, Jian-Min ^{[3
,4
]}

Stevens, Victoria L. ^{[5
]}

Weinstein, Stephanie J. ^{[6
]}

Albanes, Demetrius ^{[6
]}

Prentice, Ross ^{[8
]}

Thomsen, Cynthia A. ^{[9
]}

Pettinger, Mary ^{[6
,8
]}

Cai, Qiuyin ^{[11
,12
]}

Blot, William J. ^{[11
,12
,13
]}

Wu, Jie ^{[11
,12
]}

Arslan, Alan A. ^{[14
,15
]}

Zeleniuch-Jacquotte, Anne ^{[16
]}

McCullough, Marjorie L. ^{[5
]}

Le Marchand, Loic ^{[17
]}

Wilkens, Lynne R. ^{[17
]}

Haiman, Christopher A. ^{[17
]}

Zhang, Xuehong ^{[18
]}

Han, Jiali ^{[21
,22
,23
]}

Stampfer, Meir J. ^{[18
,21
,22
,23
,24
]}

Smith-Warner, Stephanie A. ^{[21
,22
,23
,24
]}

Giovannucci, Edward ^{[18
,21
,22
,23
,24
]}

Giles, Graham G. ^{[25
,26
]}

Hodge, Allison M. ^{[25
]}

Severi, Gianluca ^{[25
,27
,28
]}

Johansson, Mikael ^{[29
]}

Grankvist, Kjell ^{[29
]}

Langhammer, Arnulf ^{[30
]}

Krokstad, Steinar ^{[30
]}

Nss, Marit ^{[30
]}

Wang, Renwei ^{[3
]}

Gao, Yu-Tang ^{[31
]}

Butler, Lesley M. ^{[3
,4
]}

Koh, Woon-Puay ^{[32
]}

Shu, Xiao-Ou ^{[10
]}

Xiang, Yong-Bing ^{[7
]}

Li, Honglan ^{[7
]}

Zheng, Wei ^{[10
]}

Lan, Qing ^{[7
]}

Visvanathan, Kala ^{[33
,34
]}

Bolton, Judith Hoffman ^{[33
,34
]}

Ueland, Per Magne ^{[35
,36
]}

Midttun, Oivind ^{[37
]}

Ulvik, Arve ^{[37
]}

Caporaso, Neil E. ^{[6
]}

Purdue, Mark

Ziegler, Regina G.

Freedman, Neal D. ^{[6
]}

Buring, Julie E. ^{[19
,20
,21
,22
,23
]}

机构：

[1] Int Agcy Res Canc, Lyon, France

[2] Imperial Coll London, Dept Epidemiol & Biostat, London, England

[3] Univ Pittsburgh, Inst Canc, Div Canc Control & Populat Sci, Pittsburgh, PA USA

[4] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA

[5] Amer Canc Soc Inc, Epidemiol Res Program, Atlanta, GA USA

[6] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[7] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[8] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA

[9] Univ Arizona, Hlth Promot Sci Mel & Enid Zuckerman Coll Publ Hl, Tucson, AZ USA

[10] Vanderbilt Univ, Sch Med, Div Epidemiol, Dept Med, Nashville, TN 37212 USA

[11] Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA

[12] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37212 USA

[13] Int Epidemiol Inst, Rockville, MD USA

[14] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA

[15] NYU, Sch Med, Dept Populat Hlth & Environm Med, New York, NY USA

[16] NYU, Sch Med, Populat Hlth, New York, NY USA

[17] Univ Hawaii, Program Epidemiol, Canc Res Ctr Hawaii, Honolulu, HI 96822 USA

[18] Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA

[19] Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA

[20] Brigham & Womens Hosp, Div Aging, 75 Francis St, Boston, MA 02115 USA

[21] Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA

[22] Harvard Med Sch, Boston, MA USA

[23] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[24] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[25] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia

[26] Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia

[27] Human Genet Fdn, HuGeF, Mol End Epidemiol, Turin, Italy

[28] INSERM, Inst Natl Sante & Rech Med, Ctr Res Epidemiol & Populat Hlth, Villejuif, France

[29] Umea Univ, Umea, Sweden

[30] Norwegian Univ Sci & Technol, HUNT Res Ctr, Dept Publ Hlth & Gen Practice, NTNU, Levanger, Norway

[31] Shanghai Jiao Tong Univ, Dept Epidemiol, Shanghai Canc Inst, Shanghai, Peoples R China

[32] Duke NUS Grad Med Sch Singapore, Singapore, Singapore

[33] Johns Hopkins Univ, Dept Epidemiol, George W Comstock Ctr Publ Hlth Res, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[34] Johns Hopkins Univ, Prevent Hlth Monitoring Unit, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[35] Univ Bergen, Dept Clin Sci, Lab Clin Biochem, Bergen, Norway

[36] Haukeland Hosp, Bergen, Norway

[37] Bevital AS, Bergen, Norway

[38] Boston VA Med Ctr, Boston, MA USA

[39] Lund Univ, Skane Univ, Hosp Malmo, Dept Surg, Malmo, Sweden

[40] Lund Univ, Dept Clin Sci, Malmo, Sweden

[41] Lund Univ, Lund, Sweden

[42] Newcastle Univ, Inst Med Genet, Newcastle, NSW, Australia

[43] Univ Bristol, Sch Social & Community Med, MRC Integrat Epidemiol Unit, Bristol, Avon, England

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2018年 / 110卷 / 01期

基金：

美国国家卫生研究院;

关键词：

FOLIC-ACID; CUMULATIVE RISK; METABOLISM; PLASMA; SERUM; BIOMARKERS; SMOKERS;

D O I：

10.1093/jnci/djx119

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Circulating concentrations of B vitamins and factors related to one-carbon metabolismhave been found to be strongly inversely associated with lung cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The extent to which these associations are present in other study populations is unknown. Methods: Within 20 prospective cohorts from the National Cancer Institute Cohort Consortium, a nested case-control study was designed including 5364 incident lung cancer case patients and 5364 control subjects who were individually matched to case patients by age, sex, cohort, and smoking status. Centralized biochemical analyses were performed to measure circulating concentrations of vitamin B6, folate, and methionine, as well as cotinine as an indicator of recent tobacco exposure. The association between these biomarkers and lung cancer risk was evaluated using conditional logistic regression models. Results: Participants with higher circulating concentrations of vitamin B6 and folate had a modestly decreased risk of lung cancer risk overall, the odds ratios when comparing the top and bottom fourths (OR4vs1) being 0.88 (95% confidence interval [CI] = 0.78 to 1.00) and 0.86 (95% CI = 0.74 to 0.99), respectively. We found stronger associations among men (vitamin B6: OR4vs1 = 0.74, 95% CI = 0.62 to 0.89; folate: OR4vs1 = 0.75, 95% CI = 0.61 to 0.93) and ever smokers (vitamin B6: OR4vs1 = 0.78, 95% CI = 0.67 to 0.91; folate: OR4vs1 = 0.87, 95% CI = 0.73 to 1.03). We further noted that the association of folate was restricted to Europe/Australia and Asia, whereas no clear association was observed for the United States. Circulating concentrations of methionine were not associated with lung cancer risk overall or in important subgroups. Conclusions: Although confounding by tobacco exposure or reverse causation cannot be ruled out, these study results are compatible with a small decrease in lung cancer risk in ever smokers who avoid low concentrations of circulating folate and vitamin B6.

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