Overdiagnosing Vascular Dementia using Structural Brain Imaging for Dementia Work-Up

被引：13

作者：

Niemantsverdriet, Ellis ^{[1
,2
]}

Feyen, Bart F. E. ^{[1
,2
]}

Le Bastard, Nathalie ^{[1
,2
]}

Martin, Jean-Jacques ^{[1
,2
]}

Goeman, Johan ^{[3
]}

De Deyn, Peter Paul ^{[1
,2
,3
,4
,5
]}

Engelborghs, Sebastiaan ^{[1
,2
,3
]}

机构：

[1] Univ Antwerp, Reference Ctr Biol Markers Dementia BIODEM, Lab Neurochem & Behav, B-2020 Antwerp, Belgium

[2] Univ Antwerp, Inst Born Bunge, Biobank, B-2020 Antwerp, Belgium

[3] Hosp Network Antwerp, Dept Neurol & Memory Clin, Antwerp, Belgium

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands

[5] Univ Groningen, Univ Med Ctr Groningen, Alzheimer Res Ctr, Groningen, Netherlands

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2015年 / 45卷 / 04期

关键词：

Alzheimer's disease; brain imaging; dementia; differential dementia diagnosis; magnetic resonance imaging; vascular dementia; FRONTOTEMPORAL LOBAR DEGENERATION; ALZHEIMERS ASSOCIATION WORKGROUPS; MILD COGNITIVE IMPAIRMENT; NATIONAL INSTITUTE; DIAGNOSTIC GUIDELINES; DISEASE; CRITERIA; RECOMMENDATIONS; CONSORTIUM; CONSENSUS;

D O I：

10.3233/JAD-142103

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hypothesizing that non-significant cerebrovascular lesions on structural brain imaging lead to overdiagnosis of a vascular etiology of dementia as compared to autopsy-confirmed diagnosis, we set up a study including 71 patients with autopsy-confirmed diagnoses. Forty-two patients in the population (59%) appeared to have definite Alzheimer's disease (AD), whereas 29 (41%) had a non-AD dementia form. The panel clinically diagnosed possible or probable vascular dementia (VaD) in 27 (38%) patients, whereas only five (19%) patients (p = 0.017) had an autopsy-confirmed diagnosis of VaD. Patients with vascular lesions on structural brain imaging were often misdiagnosed as possible or probable VaD as compared to autopsy-confirmed diagnosis.

引用

页码：1039 / 1043

页数：5

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