Programmed Cell Death Ligand 1 Expression in Primary Central Nervous System Lymphomas: A Clinicopathological Study

被引：31

作者：

Hayano, Azusa ^{[1
]}

Komohara, Yoshihiro ^{[2
]}

Takashima, Yasuo ^{[1
]}

Takeya, Hiroto ^{[2
]}

Homma, Jumpei ^{[3
]}

Fukai, Junya ^{[5
]}

Iwadate, Yasuo ^{[6
]}

Kajiwara, Koji ^{[7
]}

Ishizawa, Shin ^{[4
]}

Hondoh, Hiroaki ^{[3
]}

Yamanaka, Ryuya ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Lab Mol Target Therapy Canc, Kyoto, Japan

[2] Kumamoto Univ, Grad Sch Med Sci, Dept Cell Pathol, Kumamoto, Japan

[3] Toyama Prefectural Cent Hosp, Dept Neurosurg, Toyama, Japan

[4] Toyama Prefectural Cent Hosp, Dept Pathol, Toyama, Japan

[5] Wakayama Med Univ, Dept Neurol Surg, Sch Med, Wakayama, Japan

[6] Chiba Univ, Grad Sch Med Sci, Dept Neurosurg, Chiba, Japan

[7] Yamaguchi Univ, Grad Sch Med Sci, Dept Neurosurg, Ube, Yamaguchi, Japan

来源：

ANTICANCER RESEARCH | 2017年 / 37卷 / 10期

基金：

日本学术振兴会;

关键词：

Primary central nervous system lymphoma; checkpoint inhibitor; diffuse large B cell lymphoma; PD-L1; tumor microenvironment; tumor-infiltrating immune cell; WHOLE-BRAIN RADIOTHERAPY; LUNG-CANCER; ANTI-PD-L1; ANTIBODY; LYMPHOCYTE SUBSETS; HODGKINS LYMPHOMA; B7-H1; EXPRESSION; PD-1; BLOCKADE; NIVOLUMAB; SAFETY; SURVIVAL;

D O I：

10.21873/anticanres.12001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Programmed cell death ligand 1 (PD-L1)/programmed cell death 1 (PD-1) have been shown to predict response to PD-L1/PD-1-targeted therapy. We analyzed PD-L1 expression in primary central nervous system lymphomas (PCNSLs). Materials and Methods: PD-L1 protein and mRNA expression were evaluated in 64 PCNSL tissue samples. IFN-gamma, IL-10, CD4, and CD8 mRNA expression was also evaluated. Results: PD-L1 protein was detected in tumor cells in 2 (4.1%) cases and in tumor microenvironments in 25 (52%) cases. PD-L1 mRNA positively correlated with IFN-gamma (p=0.0024) and CD4 (p=0.0005) mRNA expression. IFN-gamma mRNA positively correlated with CD8 mRNA expression (p=0.0001). Furthermore, tumor cell PD-L1 expression correlated positively with overall survival (p=0.0177), whereas microenvironmental PD-L1 expression exhibited an insignificant negative trend with overall survival (p=0.188). Conclusion: PD-L1 was expressed on both tumor and/or tumor-infiltrating immune cells in PCNSL. The biological roles of this marker warrant further investigation.

引用

页码：5655 / 5666

页数：12

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