Caffeine enhanced radiosensitivity of rat tumor cells with a mutant-type p53 by inducing apoptosis in a p53-independent manner

被引：25

作者：

Higuchi, K ^{[1
]}

Mitsuhashi, N ^{[1
]}

Saitoh, J ^{[1
]}

Maebayashi, K ^{[1
]}

Sakurai, H ^{[1
]}

Akimoto, T ^{[1
]}

Niibe, H ^{[1
]}

机构：

[1] Gunma Univ, Sch Med, Dept Radiol & Radiat Oncol, Gunma 3718511, Japan

来源：

CANCER LETTERS | 2000年 / 152卷 / 02期

关键词：

radiosensitization; caffeine; apoptosis; yolk sac tumor; G(2) block;

D O I：

10.1016/S0304-3835(99)00449-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The radiosensitizing effects of caffeine on two rat yolk sac tumor cell lines with a different p53 status were investigated. A reduction of radiation-induced G(2) arrest was caused by caffeine at a concentration of 2 mM in both cell lines. The reduction of survival was observed in a combination of radiation and 2 mM caffeine only in a lower radiation dose range, but not in a higher dose range in NMT-1 with a wild type p53. Radiosensitization of caffeine was recognized even in a higher dose range for cells with a mutant-type p53. Apoptosis, which was not prominent after irradiation alone or caffeine treatment alone, was induced by irradiation in combination with caffeine in cells with a mutant-type p53 through a p53-independent pathway. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：157 / 162

页数：6

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