Viral Suppressors of RNA-Based Viral Immunity: Host Targets

被引：134
作者：
Wu, Qingfa [1 ,2 ]
Wang, Xianbing [1 ,2 ]
Ding, Shou-Wei [1 ,2 ]
机构：
[1] Univ Calif Riverside, Dept Plant Pathol & Microbiol, Riverside, CA 92521 USA
[2] Univ Calif Riverside, Inst Integrat Genome Biol, Riverside, CA 92521 USA
来源：
CELL HOST & MICROBE | 2010年 / 8卷 / 01期
基金：
美国国家卫生研究院; 美国农业部;
关键词：
ANTIVIRAL DEFENSE; VIRUS-INFECTION; PROTEIN; HIV-1; ARABIDOPSIS; ARGONAUTE1; DROSOPHILA; BINDING; DEGRADATION; STRATEGY;
D O I：
10.1016/j.chom.2010.06.009
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
RNA-based viral immunity (RVI) operates in fungi, plants, and invertebrates to specifically destroy viral RNAs using the cellular RNA interference machinery. Discovery of diverse viral proteins as suppressors of RNA silencing provides strong validation for the effectiveness of RVI. Here we review recent studies that have revealed new mechanistic insights into plant and insect viral suppressors of RVI or suggested a role for RNA silencing suppression during mammalian viral infection.
引用
收藏
页码：12 / 15
页数：4
相关论文
共 31 条
[1]   Mechanism of Induction and Suppression of Antiviral Immunity Directed by Virus-Derived Small RNAs in Drosophila [J].
Aliyari, Roghiyh ;
Wu, Qingfa ;
Li, Hong-Wei ;
Wang, Xiao-Hong ;
Li, Feng ;
Green, Lance D. ;
Han, Cliff S. ;
Li, Wan-Xiang ;
Ding, Shou-Wei .
CELL HOST & MICROBE, 2008, 4 (04) :387-397
[2]   Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein [J].
Azevedo, Jacinthe ;
Garcia, Damien ;
Pontier, Dominique ;
Ohnesorge, Stephanie ;
Yu, Agnes ;
Garcia, Shahinez ;
Braun, Laurence ;
Bergdoll, Marc ;
Hakimi, Mohamed Ali ;
Lagrange, Thierry ;
Voinnet, Olivier .
GENES & DEVELOPMENT, 2010, 24 (09) :904-915
[3]   The polerovirus silencing suppressor PO targets ARGONAUTE proteins for degradation [J].
Baumberger, Nicolas ;
Tsai, Ching-Hsui ;
Lie, Miranda ;
Havecker, Ericka ;
Baulcombe, David C. .
CURRENT BIOLOGY, 2007, 17 (18) :1609-1614
[4]   Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing [J].
Bennasser, Y ;
Le, SY ;
Benkirane, M ;
Jeang, KT .
IMMUNITY, 2005, 22 (05) :607-619
[5]   The polerovirus F box protein PO targets ARGONAUTE1 to suppress RNA silencing [J].
Bortolamiol, Diane ;
Pazhouhandeh, Maghsoud ;
Marrocco, Katia ;
Genschik, Pascal ;
Ziegler-Graff, Veronique .
CURRENT BIOLOGY, 2007, 17 (18) :1615-1621
[6]   Polerovirus protein P0 prevents the assembly of small RNA-containing RISC complexes and leads to degradation of ARGONAUTE1 [J].
Csorba, Tibor ;
Lozsa, Rita ;
Hutvagner, Gyoergy ;
Burgyan, Jozsef .
PLANT JOURNAL, 2010, 62 (03) :463-472
[7]   Elimination of antiviral defense by viral RNase III [J].
Cuellar, Wilmer J. ;
Kreuze, Jan F. ;
Rajamaki, Minna-Liisa ;
Cruzado, Karin R. ;
Untiveros, Milton ;
Valkonen, Jari P. T. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (25) :10354-10358
[8]   Suppression of antiviral silencing by cucumber mosaic virus 2b protein in Arabidopsis is associated with drastically reduced accumulation of three classes of viral small interfering RNAs [J].
Diaz-Pendon, Juan A. ;
Li, Feng ;
Li, Wan-Xiang ;
Ding, Shou-Wei .
PLANT CELL, 2007, 19 (06) :2053-2063
[9]   RETRACTED: Small RNA Duplexes Function as Mobile Silencing Signals Between Plant Cells (Retracted Article) [J].
Dunoyer, Patrice ;
Schott, Gregory ;
Himber, Christophe ;
Meyer, Denise ;
Takeda, Atsushi ;
Carrington, James C. ;
Voinnet, Olivier .
SCIENCE, 2010, 328 (5980) :912-916
[10]   dsRNA with 5′ overhangs contributes to endogenous and antiviral RNA silencing pathways in plants [J].
Fukunaga, Ryuya ;
Doudna, Jennifer A. .
EMBO JOURNAL, 2009, 28 (05) :545-555
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