An eye on insulin

被引:21
作者
Bronson, SK [1 ]
Reiter, CEN [1 ]
Gardner, TW [1 ]
机构
[1] Penn State Univ, Coll Med, Dept Cell Mol Phys, Dept Ophthalmol, Hershey, PA 17033 USA
关键词
D O I
10.1172/JCI200318927
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Diabetic retinopathy, the most frequent complication of diabetes and leading cause of vision loss, involves vascular and neural damage in the retina. Insulin and IGF-1 signaling are now shown to contribute to retinal neovascularization, in part, by modulating the expression of various vascular mediators.
引用
收藏
页码:1817 / 1819
页数:3
相关论文
共 15 条
[1]   An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control [J].
Brogiolo, W ;
Stocker, H ;
Ikeya, T ;
Rintelen, F ;
Fernandez, R ;
Hafen, E .
CURRENT BIOLOGY, 2001, 11 (04) :213-221
[2]   Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization [J].
Grant, MB ;
May, WS ;
Caballero, S ;
Brown, GAJ ;
Guthrie, SM ;
Mames, RN ;
Byrne, BJ ;
Vaught, T ;
Spoerri, PE ;
Peck, AB ;
Scott, EW .
NATURE MEDICINE, 2002, 8 (06) :607-612
[3]   IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice [J].
Holzenberger, M ;
Dupont, J ;
Ducos, B ;
Leneuve, P ;
Géloën, A ;
Even, PC ;
Cervera, P ;
Le Bouc, Y .
NATURE, 2003, 421 (6919) :182-187
[4]  
Kahn CR, 2000, J PEDIATR ENDOCR MET, V13, P1377
[5]   RECEPTORS AND GROWTH-PROMOTING EFFECTS OF INSULIN AND INSULIN-LIKE GROWTH-FACTORS ON CELLS FROM BOVINE RETINAL CAPILLARIES AND AORTA [J].
KING, GL ;
GOODMAN, AD ;
BUZNEY, S ;
MOSES, A ;
KAHN, CR .
JOURNAL OF CLINICAL INVESTIGATION, 1985, 75 (03) :1028-1036
[6]   Tie2-Cre transgenic mice:: A new model for endothelial cell-lineage analysis in vivo [J].
Kisanuki, YY ;
Hammer, RE ;
Miyazaki, J ;
Williams, SC ;
Richardson, JA ;
Yanagisawa, M .
DEVELOPMENTAL BIOLOGY, 2001, 230 (02) :230-242
[7]   Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization [J].
Kondo, T ;
Vicent, D ;
Suzuma, K ;
Yanagisawa, M ;
King, GL ;
Holzenberger, M ;
Kahn, CR .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (12) :1835-1842
[8]   Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes [J].
Kulkarni, RN ;
Brüning, JC ;
Winnay, JN ;
Postic, C ;
Magnuson, MA ;
Kahn, CR .
CELL, 1999, 96 (03) :329-339
[9]   Ocular neovascularization - Clarifying complex interactions [J].
Neely, KA ;
Gardner, TW .
AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (03) :665-670
[10]   Development of the human retinal vasculature: Cellular relations and VEGF expression [J].
Provis, JM ;
Leech, J ;
Diaz, CM ;
Penfold, PL ;
Stone, J ;
Keshet, E .
EXPERIMENTAL EYE RESEARCH, 1997, 65 (04) :555-568