Long-term follow-up study of clear cell papulosis

被引:21
作者
Tseng, Fang-Wen [1 ]
Kuo, Tseng-Tong [2 ,3 ]
Lu, Pei-Hsuan [1 ,3 ]
Chan, Heng-Leong [4 ]
Chan, Ming-Jing [1 ,3 ]
Hui, Rosaline Chung-Yee [1 ,3 ]
机构
[1] Chang Gung Mem Hosp, Dept Dermatol, Taipei 10591, Taiwan
[2] Chang Gung Mem Hosp, Dept Pathol, Taipei 10591, Taiwan
[3] Chang Gung Univ, Coll Med, Taipei, Taiwan
[4] Sutein Clin, Dept Dermatol, Taipei, Taiwan
关键词
clear cell papulosis; clear cells of Toker; extramammary Paget disease; long-term follow-up; milk line; EXTRAMAMMARY PAGETS-DISEASE; TOKER CELLS; PRECURSORS; SKIN; LINK;
D O I
10.1016/j.jaad.2009.08.056
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Clear cell papulosis (CCP) was described as a new entity in 1987. Since then, only case reports or small case series have appeared in the literature and the long-term outcome of CCP remains unknown. Objectives: The aim of this study was to review cases of CCP diagnosed at our institution and to investigate their outcome. Methods: Nineteen patients given a diagnosis of CCP more than 6 years previously were identified. Their medical records and histopathologic findings were reviewed. Results: With a median follow-up duration of 11.5 years, regression of skin lesions was observed in 85.7% of patients. Persistence of skin lesions 11.5 years after diagnosis was confirmed histopathologically in one case, with a reduction in clear cell density. Limitations: Retrospective nature of the study is a limitation. Conclusion: No treatment is necessary for CCP because the skin lesions are asymptomatic and most patients experience at least partial regression. (J Am Acad Dermatol 2010;63:266-73.)
引用
收藏
页码:266 / 273
页数:8
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