DESIGN, SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL THIAZOLE AND QUINOLINE CONTAINING SCHIFF BASES AND EVALUATION OF THEIR IN-VITRO ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY

A novel and eco-friendly series of quinoline based Schiff bases (6a-f) in PEG-400hasbeensynthesized.Itcontainingtwo pharmacologically active nucleus i.e.8-hydroxyquinoline and 4-substituted phenylthiazole. The targeted compounds were obtained in good yield by reacting 2-amino-4-substitutedphenylthiazole(5a-f) with 8-hydroxyquinoline-2-carbaldehyde (4) which was obtained by oxidative product of 8-hydroxy-2-methyl quinoline (3).The molecular structures of the synthesized compounds were confirmed by physicochemical properties and spectral characteristics (IR, NMR, elemental analysis and Mass spectra). The synthesized compounds were screened for thein-vitro anti-inflammatory and antimicrobial activity.Thiazole quinoline Schiff base can be a promising molecule in developing area of antimicrobial agents for modern pharmacologists and chemists.