Noralashinol A, a new norlignan from stem barks of Syringa pinnatifolia

被引：19

作者：

Su, Guozhu ^{[1
,2
]}

Bai, Ruifeng ^{[1
,2
]}

Yu, Xuelong ^{[1
,2
]}

Cao, Yuan ^{[1
,2
]}

Yin, Xu ^{[1
,2
]}

Tu, Pengfei ^{[1
]}

Chai, Xingyun ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing, Peoples R China

[2] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 19期

基金：

中国国家自然科学基金;

关键词：

Syringa pinnatifolia; noralashinol A; anti-inflammatory activity; CHEMICAL-CONSTITUENTS; LIGNAN; ROOTS; LEAVES;

D O I：

10.1080/14786419.2016.1146886

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

One new norlignan, namely noralashinol A (1), one known analogue (2), together with seven known lignans (3-9) were isolated from the stem barks of Syringa pinnatifolia. Their structures were elucidated extensively by spectroscopic methods, including mass spectrometry and 1D and 2D NMR spectroscopies. Compound 8 significantly inhibited NO production in LPS-induced BV-2 murine microglia cells with its IC50 value of 20.7M, compared to a positive control quercetin with its IC50 value of 15.3M. [GRAPHICS] .

引用

页码：2149 / 2153

页数：5

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