Role of Transforming Growth Factor-β in Airway Remodeling in Asthma

被引：337
作者：
Halwani, Rabih [2 ,3 ]
Al-Muhsen, Saleh [2 ,3 ,4 ]
Al-Jahdali, Hamdan [2 ,3 ,5 ]
Hamid, Qutayba [1 ,2 ,3 ]
机构：
[1] McGill Univ, Meakins Christie Labs, Fac Med, Montreal, PQ H2X 2P2, Canada
[2] King Saud Univ, Asthma Res Chair, Riyadh, Saudi Arabia
[3] King Saud Univ, Prince Naif Ctr Immunol Res, Riyadh, Saudi Arabia
[4] King Saud Univ, Coll Med, Dept Pediat, Riyadh, Saudi Arabia
[5] King Saud Univ Hlth Sci, Dept Med, Riyadh, Saudi Arabia
来源：
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 2011年 / 44卷 / 02期
基金：
加拿大健康研究院;
关键词：
asthma; TGF-beta; airway remodeling; eosinophils; severe asthma; OBSTRUCTIVE PULMONARY-DISEASE; SMOOTH-MUSCLE-CELLS; MATRIX GENE-EXPRESSION; REGULATORY T-CELLS; TGF-BETA; EPITHELIAL-CELLS; EXTRACELLULAR-MATRIX; BRONCHIAL-ASTHMA; LUNG FIBROSIS; INHALED CORTICOSTEROIDS;
D O I：
10.1165/rcmb.2010-0027TR
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TGF-beta is one of the main mediators involved in tissue remodeling in the asthmatic lung. This profibrotic cytokine is produced by a number of cells, including macrophages, epithelial cells, fibroblasts, and eosinophils. High expression of TGF-beta in patients with asthma was reported by many investigators. However, controversy remains whether the concentration of TGF-beta correlates with disease severity. TGF-beta is believed to play an important role in most of the cellular biological processes leading to airway remodeling. It was shown to be involved in epithelial changes, subepithelial fibrosis, airway smooth muscle remodeling, and microvascular changes. Here, sources of TGF-beta, as well as its role in the development of airway remodeling, will be reviewed. Therapeutic strategies that modulate TGF-beta will also be discussed.
引用
收藏
页码：127 / 133
页数：7
相关论文
共 77 条
[1]   MARKED GOBLET CELL HYPERPLASIA WITH MUCUS ACCUMULATION IN THE AIRWAYS OF PATIENTS WHO DIED OF SEVERE ACUTE ASTHMA ATTACK [J].
AIKAWA, T ;
SHIMURA, S ;
SASAKI, H ;
EBINA, M ;
TAKISHIMA, T .
CHEST, 1992, 101 (04) :916-921
[2]   TRANSFORMING GROWTH-FACTOR BETA(1) GENE-EXPRESSION IN HUMAN AIRWAYS [J].
AUBERT, JD ;
DALAL, BI ;
BAI, TR ;
ROBERTS, CR ;
HAYASHI, S ;
HOGG, JC .
THORAX, 1994, 49 (03) :225-232
[3]   Increased TGF-β2 in severe asthma with eosinophilia [J].
Balzar, S ;
Chu, HW ;
Silkoff, P ;
Cundall, M ;
Trudeau, JB ;
Strand, M ;
Wenzel, S .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 115 (01) :110-117
[4]  
BRANDES ME, 1991, J IMMUNOL, V147, P1600
[5]   Transforming growth factor-β1 and disorders of the lung [J].
Camoretti-Mercado, B ;
Solway, A .
CELL BIOCHEMISTRY AND BIOPHYSICS, 2005, 43 (01) :131-148
[6]   THE STRUCTURE OF LARGE AND SMALL AIRWAYS IN NONFATAL AND FATAL ASTHMA [J].
CARROLL, N ;
ELLIOT, J ;
MORTON, A ;
JAMES, A .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 147 (02) :405-410
[7]   Airway remodeling-associated mediators in moderate to severe asthma:: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression [J].
Chakir, J ;
Shannon, J ;
Molet, S ;
Fukakusa, M ;
Elias, J ;
Laviolette, M ;
Boulet, LP ;
Hamid, Q .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 111 (06) :1293-1298
[8]   TGF-β1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases -: art. no. 2 [J].
Chen, G ;
Khalil, N .
RESPIRATORY RESEARCH, 2006, 7 (1)
[9]   Inhibition of airway remodeling in IL-5-deficient mice [J].
Cho, JY ;
Miller, M ;
Baek, KJ ;
Han, JW ;
Nayar, J ;
Lee, SY ;
McElwain, K ;
McElwain, S ;
Friedman, S ;
Broide, DH .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (04) :551-560
[10]   Transforming growth factor-β2 induces bronchial epithelial mucin expression in asthma [J].
Chu, HW ;
Balzar, S ;
Seedorf, GJ ;
Westcott, JY ;
Trudeau, JB ;
Silkoff, P ;
Wenzel, SE .
AMERICAN JOURNAL OF PATHOLOGY, 2004, 165 (04) :1097-1106
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