Cardiotoxicity

被引：65
作者：
Brana, I. [1 ]
Tabernero, J. [1 ]
机构：
[1] Vall dHebron Univ Hosp, Dept Med Oncol, Barcelona, Spain
来源：
ANNALS OF ONCOLOGY | 2010年 / 21卷
关键词：
adverse effects; antineoplastic agents; arrhythmia; chemically induced heart diseases; heart failure; QTc prolongation; ARTERIAL THROMBOEMBOLIC EVENTS; KINASE INHIBITOR; CARDIAC DYSFUNCTION; CARDIOVASCULAR TOXICITY; PHASE-I; CANCER; TRASTUZUMAB; THERAPY; CHEMOTHERAPY; BEVACIZUMAB;
D O I：
10.1093/annonc/mdq295
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer treatment has improved extraordinarily in recent years. The development of targeted therapies has widened the cardiotoxic spectrum of antineoplastic drugs. Optimum management of cardiovascular disease before and during antineoplastic treatment is essential to reduce morbidity and mortality in cancer patients. This article reviews the incidence and characteristics of cardiotoxic effects of antineoplastic drugs with special focus on the pathophysiological mechanisms. It also emphasizes the importance of early detection and correction of cardiovascular risk factors and the relevance of close cardiac monitoring during antineoplastic treatment in order to reduce cardiotoxicity.
引用
收藏
页码：173 / 179
页数：7
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