The effects of simvastatin treatment on plasma lipid-related biomarkers in men with dyslipidaemia

被引：18
作者：
Chen, Fabian [1 ]
Maridakis, Vic [1 ]
O'Neill, Edward A. [1 ]
Hubbard, Brian K. [1 ]
Strack, Alison [1 ]
Beals, Chan [1 ]
Herman, Gary A. [1 ]
Wong, Peggy [1 ]
机构：
[1] Merck Res Labs, Rahway, NJ USA
来源：
BIOMARKERS | 2011年 / 16卷 / 04期
关键词：
PCSK9; fatty acids; cardiovascular disease; atherosclerosis; hepatic lipase; lipoprotein lipase; COA REDUCTASE INHIBITORS; FATTY-ACID-COMPOSITION; LIPOPROTEIN-LIPASE; HEPATIC LIPASE; PROPROTEIN CONVERTASE; ATORVASTATIN; CHOLESTEROL; STATINS; SERUM; METABOLISM;
D O I：
10.3109/1354750X.2011.561367
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: Lipidomic biomarkers will facilitate the development of novel anti-atherosclerotic therapies. Objective: To evaluate the responses of circulating biomarkers to simvastatin treatment. Methods: A randomized, cross-over study in men with mixed dyslipidaemia was used to compare effects of simvastatin 40 mg/day with placebo. Results: Plasma concentrations of nine fatty acids (FA; of 33 evaluated) were reduced significantly by simvastatin. No changes in the rates of FA synthesis or in hepatic lipase or lipoprotein lipase activities were apparent. Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) levels increased. Conclusion: We identified lipidomic biomarkers of simvastatin treatment effect that are consistent with statin inhibition of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase (ClinicalTrials. gov:NCT00935259).
引用
收藏
页码：321 / 333
页数：13
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