The effects of simvastatin treatment on plasma lipid-related biomarkers in men with dyslipidaemia

被引：18
|
作者：
Chen, Fabian [1 ]
Maridakis, Vic [1 ]
O'Neill, Edward A. [1 ]
Hubbard, Brian K. [1 ]
Strack, Alison [1 ]
Beals, Chan [1 ]
Herman, Gary A. [1 ]
Wong, Peggy [1 ]
机构：
[1] Merck Res Labs, Rahway, NJ USA
来源：
BIOMARKERS | 2011年 / 16卷 / 04期
关键词：
PCSK9; fatty acids; cardiovascular disease; atherosclerosis; hepatic lipase; lipoprotein lipase; COA REDUCTASE INHIBITORS; FATTY-ACID-COMPOSITION; LIPOPROTEIN-LIPASE; HEPATIC LIPASE; PROPROTEIN CONVERTASE; ATORVASTATIN; CHOLESTEROL; STATINS; SERUM; METABOLISM;
D O I：
10.3109/1354750X.2011.561367
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: Lipidomic biomarkers will facilitate the development of novel anti-atherosclerotic therapies. Objective: To evaluate the responses of circulating biomarkers to simvastatin treatment. Methods: A randomized, cross-over study in men with mixed dyslipidaemia was used to compare effects of simvastatin 40 mg/day with placebo. Results: Plasma concentrations of nine fatty acids (FA; of 33 evaluated) were reduced significantly by simvastatin. No changes in the rates of FA synthesis or in hepatic lipase or lipoprotein lipase activities were apparent. Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) levels increased. Conclusion: We identified lipidomic biomarkers of simvastatin treatment effect that are consistent with statin inhibition of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase (ClinicalTrials. gov:NCT00935259).
引用
收藏
页码：321 / 333
页数：13
相关论文
共 50 条
  • [21] Maternal cysteine intake influenced oxidative status and lipid-related gut microbiota and plasma metabolomics in male suckling piglets
    Ni, Hengjia
    Long, Lina
    Bin, Peng
    Azad, Md. Abul Kalam
    Xu, Kang
    Zhou, Xihong
    Ding, Xinghua
    Liu, Gang
    ANIMAL FEED SCIENCE AND TECHNOLOGY, 2021, 276
  • [22] Novel Data on the Pathogenesis of Atherosclerosis, Treatment Targets, and New Therapeutic Interventions in Lipid-Related Cardiovascular Risk Factors
    Athyros, Vasilios G.
    Tziomalos, Konstantinos
    Katsiki, Niki
    Mikhailidis, Dimitri P.
    CURRENT PHARMACEUTICAL DESIGN, 2014, 20 (40) : 6215 - 6219
  • [23] Effects of dietary polyunsaturated fatty acid sources on lipid-related genes in bovine milk somatic cells.
    Vargas-Bello-Perez, E.
    Cancino-Padilla, N.
    Geldsetzer-Mendoza, C.
    Morales, M. S.
    Leskinen, H.
    Garnsworthy, P. C.
    Loor, J. J.
    Romero, J.
    JOURNAL OF DAIRY SCIENCE, 2020, 103 : 98 - 99
  • [24] Effects of dietary polyunsaturated fatty acid sources on expression of lipid-related genes in bovine milk somatic cells
    Vargas-Bello-Perez, Einar
    Cancino-Padilla, Nathaly
    Geldsetzer-Mendoza, Carolina
    Morales, Maria Sol
    Leskinen, Heidi
    Garnsworthy, Philip C.
    Loor, Juan J.
    Romero, Jaime
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [25] Fish as models to study liver and blood lipid-related effects of fibrates and statins and screen new hypolipidemic drugs
    Lourenco, Tiago
    Madureira, Tania Vieira
    Rocha, Maria Joao
    Rocha, Eduardo
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2023, 274
  • [26] Sex-related differences in response of plasma lipids to simvastatin: The Saitama Postmenopausal Lipid Intervention Study
    Nakajima, K
    CLINICAL THERAPEUTICS, 1999, 21 (12) : 2047 - 2057
  • [27] Effects of perilla extract on productive performance, serum values and hepatic expression of lipid-related genes in Shaoxing ducks
    Liu, W. M.
    Zhang, J.
    Lu, L. Z.
    Shi, F. X.
    Niu, D.
    Wang, D. L.
    Yu, B.
    Tao, Z. R.
    Shen, J. D.
    Wang, D. Q.
    Tian, Y.
    BRITISH POULTRY SCIENCE, 2011, 52 (03) : 381 - 387
  • [28] Effects of dietary polyunsaturated fatty acid sources on expression of lipid-related genes in bovine milk somatic cells
    Einar Vargas-Bello-Pérez
    Nathaly Cancino-Padilla
    Carolina Geldsetzer-Mendoza
    María Sol Morales
    Heidi Leskinen
    Philip C. Garnsworthy
    Juan J. Loor
    Jaime Romero
    Scientific Reports, 10
  • [29] PREDICTING CORONARY ARTERY CALCIFICATION USING TRADITIONAL AND NOVEL LIPID-RELATED BIOMARKERS IN UNTREATED PATIENTS WITH ANGINA-LIKE CHEST PAIN
    Peng, J.
    Li, J. -J.
    ATHEROSCLEROSIS, 2021, 331 : E117 - E117
  • [30] Detailed Lipid Profiles and Lipid-related Residual Risk after 12-week 10 mg Rosuvastatin Treatment for Acute Myocardial Infarction
    Kondo, Yuki
    Ishida, Masaru
    Ishisone, Takenori
    Niiyama, Masanobu
    Osaki, Takuya
    Matsumoto, Yuki
    Maegawa, Yuko
    Sasaki, Kenta
    Ninomiya, Ryo
    Takahashi, Yuji
    Ishikawa, Yu
    Kimura, Takumi
    Shimoda, Yudai
    Morikawa, Munetaka
    Saito, Hidenori
    Itoh, Tomonori
    Morino, Yoshihiro
    INTERNAL MEDICINE, 2024, 63 (22) : 3031 - 3038
12345