The American Society of Transplantation Consensus Conference on the Use of Hepatitis C Viremic Donors in Solid Organ Transplantation

被引：244

作者：

Levitsky, J. ^{[1
]}

Formica, R. N. ^{[2
]}

Bloom, R. D. ^{[3
]}

Charlton, M. ^{[4
]}

Curry, M. ^{[5
]}

Friedewald, J. ^{[1
]}

Friedman, J. ^{[6
]}

Goldberg, D. ^{[3
]}

Hall, S. ^{[7
]}

Ison, M. ^{[1
]}

Kaiser, T. ^{[8
]}

Klassen, D. ^{[9
]}

Klintmalm, G. ^{[7
]}

Kobashigawa, J. ^{[10
]}

Liapakis, A. ^{[2
]}

O'conner, K. ^{[11
]}

Reese, P. ^{[3
]}

Stewart, D. ^{[9
]}

Terrault, N. ^{[12
]}

Theodoropoulos, N. ^{[13
]}

Trotter, J. ^{[7
]}

Verna, E. ^{[14
]}

Volk, M. ^{[15
]}

机构：

[1] Northwestern Univ, Chicago, IL 60611 USA

[2] Yale Univ, New Haven, CT USA

[3] Univ Penn, Philadelphia, PA 19104 USA

[4] Intermt Med Ctr, Salt Lake City, UT USA

[5] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[6] Optum Populat Hlth Solut, Minneapolis, MN USA

[7] Baylor Univ, Med Ctr, Dallas, TX USA

[8] Univ Cincinnati, Cincinnati, OH USA

[9] United Network Organ Sharing, Richmond, VA USA

[10] Cedars Sinai Heart Inst, Los Angeles, CA USA

[11] LifeCtr Norwest, Seattle, WA USA

[12] Univ Calif San Francisco, San Francisco, CA 94143 USA

[13] Univ Massachusetts, Worcester, MA 01605 USA

[14] Columbia Univ, New York, NY USA

[15] Loma Linda Univ, San Diego, CA USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2017年 / 17卷 / 11期

关键词：

SQUAMOUS-CELL CARCINOMA; MYCOPHENOLATE-MOFETIL; MAMMALIAN TARGET; CYCLOSPORINE-A; KIDNEY-TRANSPLANTATION; RENAL-TRANSPLANTATION; SEBACEOUS HYPERPLASIA; VORICONAZOLE THERAPY; GINGIVAL OVERGROWTH; ULCERATIVE-COLITIS;

D O I：

10.1111/ajt.14381

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The availability of direct-acting antiviral agents for the treatment of hepatitis C virus (HCV) infection has resulted in a profound shift in the approach to the management of this infection. These changes have affected the practice of solid organ transplantation by altering the framework by which patients with end-stage organ disease are managed and receive organ transplants. The high level of safety and efficacy of these medications in patients with chronic HCV infection provides the opportunity to explore their use in the setting of transplanting organs from HCV-viremic patients into non-HCV-viremic recipients. Because these organs are frequently discarded and typically come from younger donors, this approach has the potential to save lives on the solid organ transplant waitlist. Therefore, an urgent need exists for prospective research protocols that study the risk versus benefit of using organs for hepatitis C-infected donors. In response to this rapidly changing practice and the need for scientific study and consensus, the American Society of Transplantation convened a meeting of experts to review current data and develop the framework for the study of using HCV viremic organs in solid organ transplantation.

引用

页码：2790 / 2802

页数：13

共 83 条

[1] ISOTRETINOIN TREATMENT OF SEVERE CYSTIC ACNE IN A HEART-TRANSPLANT PATIENT RECEIVING CYCLOSPORINE - CONSIDERATION OF DRUG-INTERACTIONS [J].