Mechanisms of tolerance and allergic sensitization in the airways and the lungs

被引：32

作者：

de Lafaille, Maria A. Curotto

Lafaille, Juan J. ^{[1
,2
]}

Graca, Luis ^{[3
]}

机构：

[1] NYU, Mol Pathogenesis Program, Kimmel Ctr Biol & Med, Skirball Inst Biomol Med,Sch Med, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

[3] Univ Lisbon, Inst Mol Med, Fac Med, P-1649028 Lisbon, Portugal

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 05期

关键词：

REGULATORY T-CELLS; THYMIC STROMAL LYMPHOPOIETIN; TRANSCRIPTION FACTOR FOXP3; BOUND TGF-BETA; IN-VIVO; INHALED ANTIGEN; DENDRITIC CELLS; IMMUNE-RESPONSES; HEME OXYGENASE-1; EPITHELIAL-CELL;

D O I：

10.1016/j.coi.2010.08.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The respiratory mucosa is constantly exposed to non-infectious substances that have the potential of triggering inflammation While many particles are excluded soluble molecules can reach the epithelium surface where they can be uptaken by dendritic cells and stimulate an adaptive immune response Most mucosal responses result in tolerance to subsequent antigen encounters which is mediated by Foxp3(+) regulatory T cells Genetic and environmental factors added to the ability of certain allergens to induce innate responses can predispose to allergic sensitization In this review we discuss recent advances in the understanding of the mechanisms of tolerance and allergic sensitization to airborne allergens

引用

页码：616 / 622

页数：7

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