Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women

被引：23

作者：

Schoemaker, Minouk J. ^{[1
]}

Nichols, Hazel B. ^{[2
]}

Wright, Lauren B. ^{[1
]}

Brook, Mark N. ^{[1
]}

Jones, Michael E. ^{[1
]}

O'Brien, Katie M. ^{[3
]}

Adami, Hans-Olov ^{[4
,5
]}

Baglietto, Laura ^{[6
]}

Bernstein, Leslie ^{[7
]}

Bertrand, Kimberly A. ^{[8
]}

Boutron-Ruault, Marie-Christine ^{[6
]}

Chen, Yu ^{[9
,10
]}

Connor, Avonne E. ^{[11
,12
]}

Dossus, Laure ^{[13
]}

Eliassen, A. Heather ^{[14
,15
,16
]}

Giles, Graham G. ^{[17
,18
]}

Gram, Inger T. ^{[19
]}

Hankinson, Susan E. ^{[20
]}

Kaaks, Rudolf ^{[21
]}

Key, Timothy J. ^{[22
]}

Kirsh, Victoria A. ^{[23
]}

Kitahara, Cari M. ^{[24
]}

Larsson, Susanna C. ^{[25
]}

Linet, Martha ^{[24
]}

Ma, Huiyan ^{[7
]}

Milne, Roger L. ^{[17
,18
]}

Ozasa, Kotaro ^{[26
]}

Palmer, Julie R. ^{[8
]}

Riboli, Elio ^{[27
]}

Rohan, Thomas E. ^{[28
]}

Sacerdote, Carlotta ^{[29
,30
]}

Sadakane, Atsuko ^{[26
]}

Sund, Malin ^{[31
]}

Tamimi, Rulla M. ^{[14
,15
,16
]}

Trichopoulou, Antonia ^{[32
]}

Ursin, Giske ^{[33
,34
,35
]}

Visvanathan, Kala ^{[11
,36
]}

Weiderpass, Elisabete ^{[37
]}

Willett, Walter C. ^{[14
,15
,16
]}

Wolk, Alicja ^{[25
,38
]}

Zeleniuch-Jacquotte, Anne ^{[9
,10
]}

Sandler, Dale P. ^{[39
]}

Swerdlow, Anthony J. ^{[1
,40
]}

机构：

[1] Inst Canc Res, Div Genet & Epidemiol, London, England

[2] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA

[3] NIEHS, Biostat & Computat Biol Branch, NIH, Durham, NC USA

[4] Karolinska Inst, Dept Med Epidemiol & Biostat MEB, Stockholm, Sweden

[5] Univ Oslo, Inst Hlth & Soc, Clin Effectiveness Res Grp, Oslo, Norway

[6] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

[7] Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA USA

[8] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA

[9] NYU, Sch Med, Dept Populat Hlth, New York, NY USA

[10] NYU, Sch Med, Perlmutter Canc Ctr, New York, NY USA

[11] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[12] Johns Hopkins Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

[13] Int Agcy Res Canc, Nutr & Metab Sect, Lyon, France

[14] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[15] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA

[16] Harvard Med Sch, Boston, MA 02115 USA

[17] Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia

[18] Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia

[19] Univ Tromso UiT, Dept Community Med, Fac Hlth Sci, Tromso, Norway

[20] Univ Massachusetts, Dept Biostat & Epidemiol, Sch Publ Hlth & Hlth Sci, Amherst, MA 01003 USA

[21] DKFZ, Div Canc Epidemiol, Heidelberg, Germany

[22] Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

[23] Ontario Inst Canc Res, Toronto, ON, Canada

[24] NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[25] Karolinska Inst, Inst Environm Med, Stockholm, Sweden

[26] Radiat Effects Res Fdn, Hiroshima, Japan

[27] Imperial Coll, Sch Publ Hlth, London, England

[28] Albert Einstein Coll Med, Bronx, NY 10467 USA

[29] Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy

[30] Ctr Canc Prevent CPO, Turin, Italy

[31] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[32] Hellen Hlth Fdn, Athens, Greece

[33] Inst Populat Based Canc Res, Canc Registry Norway, Oslo, Norway

[34] Univ Oslo, Inst Basic Med Sci, Oslo, Norway

[35] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USA

[36] Johns Hopkins Sch Med, Baltimore, MD USA

[37] WHO, IARC, Lyon, France

[38] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden

[39] NIEHS, Epidemiol Branch, NIH, Durham, NC USA

[40] Inst Canc Res, Div Breast Canc Res, London, England

来源：

INTERNATIONAL JOURNAL OF CANCER | 2020年 / 147卷 / 05期

基金：

英国医学研究理事会; 美国国家卫生研究院; 瑞典研究理事会;

关键词：

breast neoplasms; premenopause; body weight changes; risk factors; cohort studies; BODY-MASS INDEX; MAMMOGRAPHIC DENSITY; PHYSICAL-ACTIVITY; SEX-HORMONES; BIRTH-WEIGHT; EARLY-LIFE; SIZE; COHORT; OVERWEIGHT; REGRESSION;

D O I：

10.1002/ijc.32892

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18-24 years and other breast cancer risk factors showed that weight gain from ages 18-24 to 35-44 or to 45-54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.95-0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.94-0.98). Weight gain from ages 25-34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35-44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45-54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.

引用

页码：1306 / 1314

页数：9

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