Assessment of therapeutic potential of Cell free supernatant of Pediococcus acidilactici NCDC 252: a novel potential probiotic of dairy origin

被引：0
作者：
Raman, Kumar [2 ]
Poonam, Bansal [1 ]
Jasbir, Singh [2 ]
Suman, Dhanda [2 ]
机构：
[1] Maharishi Markandeshwar Deemed Be Univ, Dept Biotechnol, Mullana Ambala 133207, Haryana, India
[2] Kurukshetra Univ, Dept Biochem, Kurukshetra 136119, Haryana, India
来源：
RESEARCH JOURNAL OF BIOTECHNOLOGY | 2022年 / 17卷 / 06期
关键词：
Probiotics; Pediococcus acidilactici NCDC 252; Cell free supernatant; Antimicrobial; Antimalarial; Anticancer; LACTIC-ACID BACTERIA; CANCER; STRAINS; LACTOBACILLI; PREVENTION; MECHANISMS; PEPTIDES; GROWTH; FOOD;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Health promoting activities of probiotics are attributed to probiotic-derived probioceuticals. These are biologically active metabolites that enhance human health either by augmenting human immunity or by inhibiting/neutralizing pathogens. Antimicrobial, antimalarial and anticancer potential of cell free supernatant (CFS) of NCDC 252 was studied using standard assays, CFS exhibited strong antimicrobial activity against studied pathogenic microbes. Neutralization studies confirmed the presence of organic acids in CFS. Enzymatic treatment of CFS revealed ITS proteinous nature. CFS also prevented biofilm formation by pathogens, exhibited antiplasmodial activity and revealed cytotoxicity against colon cancer cells. All these activities suggest a spectrum of beneficial effects of NCDC 252 mediated through CFS. Isolation of active principle will help in selective therapeutic use of NCDC 252.
引用
收藏
页码：59 / 66
页数：8
相关论文
共 44 条
[1]   Impact of perioperative probiotic treatment for surgical site infections in patients with colorectal cancer [J].
Aisu, Naoya ;
Tanimura, Shu ;
Yamashita, Yuichi ;
Yamashita, Kanefumi ;
Maki, Kenji ;
Yoshida, Yoichiro ;
Sasaki, Takamitsu ;
Takeno, Shinsuke ;
Hoshino, Seiichiro .
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2015, 10 (03) :966-972
[2]  
Aween Mohamed Mustafa, 2012, American Journal of Applied Sciences, V9, P807
[3]   Characterization and Antibacterial Potential of Lactic Acid Bacterium Pediococcus pentosaceus 4l1 Isolated from Freshwater Fish Zacco koreanus [J].
Bajpai, Vivek K. ;
Han, Jeong-Ho ;
Rather, Irfan A. ;
Park, Chanseo ;
Lim, Jeongheui ;
Paek, Woon Kee ;
Lee, Jong Sung ;
Yoon, Jung-In ;
Park, Yong-Ha .
FRONTIERS IN MICROBIOLOGY, 2016, 7
[4]  
Bintsis T, 2017, AIMS MICROBIOL, V3, P529, DOI 10.3934/microbiol.2017.3.529
[5]   Antagonistic Activities and Probiotic Potential of Lactic Acid Bacteria Derived From a Plant-Based Fermented Food [J].
Choi, Ah-Rang ;
Patra, Jayanta Kumar ;
Kim, Wang June ;
Kang, Seok-Seong .
FRONTIERS IN MICROBIOLOGY, 2018, 9
[6]   A potential role of probiotics in colorectal cancer prevention: review of possible mechanisms of action [J].
Chong, Esther Swee Lan .
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2014, 30 (02) :351-374
[7]   Antibacterial and Antibiofilm Activity of Lactic Acid Bacteria Isolated from Traditional Artisanal Milk Cheese from Northeast China Against Enteropathogenic Bacteria [J].
Cui, Xingyang ;
Shi, Yunjia ;
Gu, Shanshan ;
Yan, Xin ;
Chen, Hongyan ;
Ge, Junwei .
PROBIOTICS AND ANTIMICROBIAL PROTEINS, 2018, 10 (04) :601-610
[8]   Review of the mechanisms of probiotic actions in the prevention of colorectal cancer [J].
dos Reis, Sandra A. ;
da Conceicao, Lisiane L. ;
Siqueira, Nathane P. ;
Rosa, Damiana D. ;
da Silva, Leticia L. ;
Peluzio, Maria do Carmo G. .
NUTRITION RESEARCH, 2017, 37 :1-19
[9]   Cytotoxic effects of various lactic acid bacteria on Caco-2 cells [J].
Er, Sevda ;
Koparal, Ayse Tansu ;
Kivanc, Merih .
TURKISH JOURNAL OF BIOLOGY, 2015, 39 (01) :23-30
[10]   In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin [J].
Fang, Yaqun ;
He, Xiaoqin ;
Zhang, Pengcheng ;
Shen, Chuanbin ;
Mwangi, James ;
Xu, Cheng ;
Mo, Guoxiang ;
Lai, Ren ;
Zhang, Zhiye .
TOXINS, 2019, 11 (07)
12345