Degradability and Osteogenesis of Mesoporous Magnesium Silicate Modified Calcium Sulphate Bone Cement

被引：1

作者：

Chen Jie ^{[1
]}

Dong Xie-Ping ^{[2
]}

Liu Zheng-Hui ^{[1
]}

Hu-Xing-Long ^{[1
]}

Wei Jie ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

[2] Jiangxi Peoples Hosp, Dept Orthopaed Surg, Nanchang 330006, Peoples R China

来源：

CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2016年 / 32卷 / 06期

关键词：

mesoporous magnesium silicate; calcium sulfate; composite bone cement; degradability; osteogenesis; IN-VITRO; DEGRADATION; PHOSPHATE; CERAMICS; GLASS;

D O I：

10.11862/CJIC.2016.125

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel bone cement of mesoporous magnesium silicate and calcium sulfate composite (m-MSC) was fabricated by introducing mesoporous magnesium silicate (m-MS) into calcium sulfate bone cement (CS). The results showed that the addition of m-MS into CS prolonged the setting time and promoted the degradability of the m-MSC, and neutralized acid substance produced by CS degradation. In cell culture experiments, the result showed that the m-MSC could promote the proliferation and differentiation of MC3T3-E1 cells. In addition, the results of m-MSC histological elevation from bone trauma model revealed that massive bony tissue and Col- I formed were better than CS after 12 weeks, indicating good osteogenesis of the m-MSC.

引用

页码：935 / 944

页数：10

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