PCSK9 DEFICIENCY PROTECTS AGAINST ISCHEMIC STROKE BUT INCREASES HEMORRHAGIC TRANSFORMATION IN A HYPERGLYCEMIC MOUSE MODEL

被引:0
|
作者
Nativel, B. [1 ]
Mangata, S. Ramin [1 ]
Meilhac, O. [1 ]
Lambert, G. [1 ]
Bourane, S. [1 ]
机构
[1] Univ La Reunion, Lab Detroi, St Clotilde, Reunion, France
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
P118
引用
收藏
页码:E95 / E95
页数:1
相关论文
共 50 条
  • [1] PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Inhibition in Hyperglycemic Mice Increases the Risk of Hemorrhagic Transformation of Ischemic Stroke
    Nativel, Brice
    Ramin-Mangata, Stephane
    Couret, David
    Planesse, Cynthia
    Roche, Mathias
    Gallo, Antonio
    Meilhac, Olivier
    Lambert, Gilles
    Bourane, Steeve
    STROKE, 2021, 52 (09) : E545 - E547
  • [2] EFFECTS OF PCSK9 VARIANTS AND PCSK9 LEVELS ON RISK OF ISCHEMIC STROKE
    Chen, W.
    Pan, Y.
    Wang, Y.
    Li, H.
    Meng, X.
    Wang, Y.
    INTERNATIONAL JOURNAL OF STROKE, 2020, 15 (1_SUPPL) : 629 - 629
  • [3] Ischemic Postconditioning Protects Against Hemorrhagic Transformation Induced by Hyperglycemia in Ischemic Stroke
    Chen Hansen
    Cheng, Michelle Y.
    Bliss, Tonya
    Zhao Heng
    Steinberg, Gary
    STROKE, 2021, 52
  • [4] PCSK9 Base Editing Therapeutics and Ischemic Stroke
    Wagner, Josephin
    Bell, Andrew S.
    Lohoff, Falk W.
    ACS CHEMICAL NEUROSCIENCE, 2022, 13 (23): : 3210 - 3212
  • [5] Very low levels of LDL-cholesterol associated with PCSK9 inhibition do not increase the risk of hemorrhagic transformation after ischemic stroke
    Tran-Dinh, A.
    Levoye, A.
    Lapergue, B.
    Desilles, J. P.
    Lambert, G.
    Meilhac, O.
    Amarenco, P.
    CEREBROVASCULAR DISEASES, 2014, 37 : 333 - 334
  • [6] Real Life Utility Of PCSK9 Inhibitors Following Ischemic Stroke
    Arons, Danielle
    Grimes, Kathryn
    Mehndiratta, Prachi
    Chaturvedi, Seemant
    STROKE, 2023, 54
  • [7] Impact of PCSK9 in a murine mouse model of sepsis
    Dwivedi, D. J.
    Khan, M.
    Lysov, Z.
    Prat, A.
    Fox-Robichaud, A. E.
    Seidah, N. G.
    Liaw, P. C.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2015, 13 : 379 - 379
  • [8] PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Status and Protection Against Ischemic Stroke PheWAS, TreWAS, and More
    Sullivan, David
    Bonnitcha, Paul
    Spinks, Catherine
    Keech, Tony
    CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2018, 11 (07):
  • [9] PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke
    Rousselet, Estelle
    Marcinkiewicz, Jadwiga
    Kriz, Jasna
    Zhou, Ann
    Hatten, Mary E.
    Prat, Annik
    Seidah, Nabil G.
    JOURNAL OF LIPID RESEARCH, 2011, 52 (07) : 1383 - 1391
  • [10] Possible association of PCSK9 expression and inflammation in acidic condition by ischemic stroke
    Mizuma, A.
    Fujii, N.
    Kohara, S.
    Yuzawa, H.
    Nagata, E.
    Takizawa, S.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2019, 39 : 452 - 452