PEG-embedded thiourea dioxide (PEG.TUD) as a novel organocatalyst for the highly efficient synthesis of 3,4-dihydropyrimidinones

被引：64

作者：

Verma, Sanny ^{[1
]}

Jain, Suman L. ^{[1
]}

Sain, Bir ^{[1
]}

机构：

[1] Indian Inst Petr, Council Ind & Sci Res, Div Chem Sci, Dehra Dun 248005, Uttar Pradesh, India

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 52期

关键词：

Host-guest complex; Organocatalyst; Thiourea; Biginelli; Green method; BAYLIS-HILLMAN REACTION; SOLVENT-FREE CONDITIONS; BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS; CALCIUM-CHANNEL BLOCKERS; ASYMMETRIC ORGANOCATALYSIS; MULTICOMPONENT REACTIONS; DOMINO REACTIONS; MANNICH REACTION; ALDOL REACTIONS; ACID-ESTERS;

D O I：

10.1016/j.tetlet.2010.10.124

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The host-guest complex between polyethylene glycol and thiourea dioxide (PEG.TUD) was prepared via different approaches involving co-crystallization method and by a chemical reaction. The resulting PEG.TUD complex was found to be very active and recyclable catalyst for the direct synthesis of 3,4-dihydropyrimidinones via Biginelli condensation and provided high product yields. Interestingly, the corresponding poly(ethylene glycol)-thiourea complexes, PEG.TU, were found to be unreactive and no reaction occurred under similar reaction conditions. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6897 / 6900

页数：4

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