Inhibition of class II major histocompatibility complex antigen processing by Escherichia coli heat-labile enterotoxin requires an enzymatically active a subunit

被引：27
作者：
Matousek, MP
Nedrud, JG
Cieplak, W
Harding, CV
机构：
[1] Case Western Reserve Univ, Inst Pathol, Dept Pathol, Cleveland, OH 44106 USA
[2] NIAID, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA
来源：
INFECTION AND IMMUNITY | 1998年 / 66卷 / 07期
关键词：
D O I：
10.1128/IAI.66.7.3480-3484.1998
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT) were found to inhibit intracellular antigen processing. Processing was not inhibited by mutant LT with attenuated ADP-ribosyltransferase activity, CT B or LT B subunit, which enhanced presentation of preexisting cell surface peptide-class II major histocompatibility complex complexes. Inhibition of antigen processing correlated with A subunit ADP-ribosyltransferase activity.
引用
收藏
页码：3480 / 3484
页数：5
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