Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling

被引：6

作者：

Koo, Hyun Jung ^{[1
]}

Lee, SungRyul ^{[2
]}

Chang, Kwang Jin ^{[1
]}

Sohn, Eunsoo ^{[3
]}

Sohn, Eun-Hwa ^{[4
]}

Kang, Se Chan ^{[5
]}

Pyo, Suhkneung ^{[6
]}

机构：

[1] Korea Natl Coll Agr & Fisheries, Dept Med & Ind Crops, Jeonju 54874, South Korea

[2] Inje Univ, Coll Med, Cardiovasc & Metab Dis Ctr, Dept Integrated Biomed Sci, Busan 47392, South Korea

[3] Korea Inst Sci & Technol Informat, Dept Scientometr Res, Seoul, South Korea

[4] Kangwon Natl Univ, Dept Herbal Med Resources, Samcheok 25913, South Korea

[5] Kyung Hee Univ, Coll Life Sci, Dept Oriental Med Biotechnol, Yongin 17104, South Korea

[6] Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 92卷

基金：

新加坡国家研究基金会;

关键词：

ApoE; Dioscorea batatas Decne; Inflammation; Toll-like receptor 4; Activator protein 1; HepG2; FATTY LIVER-DISEASE; APOLIPOPROTEIN-E; BETA-SITOSTEROL; NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME; KNOCKOUT MICE; INFLAMMATION; EXPRESSION; FIBROSIS; ACTIVATION;

D O I：

10.1016/j.biopha.2017.05.036

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The hepatic anti-inflammatory potential of hexane extracts of Dioscorea batatas Decne edible part (EDH-1e) and bark (EDH-2b) were investigated in Western-type diet-fed apolipoprotein E null [ApoE (-/-)] mice and HepG2 cells. EDH-1e and EDH-2b suppressed the increased levels of tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, transforming growth factor beta 1 (TGF-beta 1), vascular cell adhesion protein 1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1), and reduced infiltration of monocytes into liver tissue. The protein levels of Toll-like receptor 4 (TLR4) were also downregulated by EDH-1e and EDH-2b treatment as were the levels of activator protein 1 (AP-1), c-fos, and c-jun in the livers from Western-type diet-fed ApoE (-/-) mice and in lipopolysaccharide-stimulated HepG2 cells. Taken together, EDH-1e and EDH-2b attenuated hepatic inflammation and fibrosis via suppression of the TLR4-AP1-mediated signaling pathway. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：157 / 167

页数：11

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