A90720A, a serine protease inhibitor isolated from a terrestrial blue-green alga Microchaete loktakensis

被引：49

作者：

Bonjouklian, R ^{[1
]}

Smitka, TA ^{[1
]}

Hunt, AH ^{[1
]}

Occolowitz, JL ^{[1
]}

Perun, TJ ^{[1
]}

Doolin, L ^{[1
]}

Stevenson, S ^{[1
]}

Knauss, L ^{[1
]}

Wijayaratne, R ^{[1
]}

Szewczyk, S ^{[1
]}

Patterson, GML ^{[1
]}

机构：

[1] UNIV HAWAII,DEPT CHEM,HONOLULU,HI 96822

来源：

TETRAHEDRON | 1996年 / 52卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0040-4020(95)00857-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The isolation and structure elucidation of A90720A,1, a cyclic depsipeptide from the terrestrial blue-green alga Microchaete loktakensis is described. 1 was isolated on the basis of its thrombin inhibitory activity and its structure was determined using spectral methods and amino acid analysis. The absolute configurations of the constituent amino acids were found to be as follows: the nucleus contains L-threonine, L-arginine, L-3-amino-6-hydroxy-2-piperidone (Ahp, i.e., glutamic acid-gamma-carboxaldehyde), L-leucine, L-N-methyl-tyrosine and L-valine. The side chain off the L-threonine amino group contains D-leucine, followed by a 3-O-sulfated R-glycerate moiety.

引用

页码：395 / 404

页数：10

共 13 条

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