Antimicrobial activity and resistance selection of different bioglass S53P4 formulations against multidrug resistant strains

被引：60
作者：
Drago, Lorenzo [1 ,2 ]
De Vecchi, Elena [1 ]
Bortolin, Monica [1 ]
Toscano, Marco [1 ]
Mattina, Roberto [3 ]
Romano, Carlo Luca [4 ]
机构：
[1] IRCCS Galeazzi Orthopaed Inst, Lab Clin Chem & Microbiol, I-20161 Milan, Italy
[2] Univ Milan, Dept Biomed Sci Hlth, Lab Tech Sci, Lab Med, I-20133 Milan, Italy
[3] Univ Milan, Dept Publ Hlth Microbiol & Virol, I-20133 Milan, Italy
[4] IRCCS Galeazzi Orthopaed Inst, Ctr Reconstruct Surg & Bone Infect, I-20161 Milan, Italy
来源：
FUTURE MICROBIOLOGY | 2015年 / 10卷 / 08期
关键词：
antibacterial activity; bioactive glass S53P4; bone infection; multidrug resistance; scanning electron microscopy; selection of resistance; BIOACTIVE GLASS S53P4; IN-VITRO; CHRONIC OSTEOMYELITIS; BONE; BACTERIA; INFECTIONS; FRACTURES;
D O I：
10.2217/FMB.15.57
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aims: This study aimed to evaluate the antimicrobial activity of two different formulations of bioglass BAG-S53P4 against multiresistant microorganisms involved in bone infections, and the capability of bioglass to select for resistance. Methods: Antibacterial activity was evaluated by means of killing curves. The ability to select for resistant bacteria was evaluated by subculturing microorganisms in serial dilutions of bioglass. Scanning electron microscope acquisitions were conducted to evaluate bioglass-induced morphology changes. Results: BAG-S53P4 formulations display a high antimicrobial activity and do not seem to select for resistance. Scanning electron microscopy analysis showed cell shrinkage and membrane damage after exposure to bioglass. Conclusions: BAG-S53P4 has a significant potential as bone substitute for the treatment of infections caused by multiresistant microorganisms.
引用
收藏
页码：1293 / 1299
页数：7
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