Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis:: Evidence of a weak association in Finns

被引：0

作者：

Pointon, Jennifer J. ^{[1
]}

Chapman, Kay ^{[1
]}

Harvey, David ^{[1
]}

Sims, Anne-Marie ^{[2
]}

Bradbury, Linda ^{[2
]}

Laiho, Kari ^{[3
,4
]}

Kauppi, Markku

Kaarela, Kalevi ^{[3
]}

Tuomilehto, Jaakko ^{[5
,6
]}

Brown, Matthew A. ^{[7
]}

Wordsworth, B. Paul ^{[1
]}

机构：

[1] Univ Oxford, Inst Musculoskeletal Sci, Botnar Res Ctr, Oxford OX3 7LD, England

[2] Univ Queensland, Diamantina Inst Canc Immunol & Metab Med, Brisbane, Qld, Australia

[3] Rheumatism Fdn Hosp, SF-18120 Heinola, Finland

[4] Univ Tampere, Sch Med, Dept Musculoskeletal Med, FIN-33101 Tampere, Finland

[5] Univ Helsinki, Natl Publ Hlth Inst, Helsinki, Finland

[6] S Ostrobothnia Cent Hosp, Seinajoki, Finland

[7] Univ Oxford, Inst Musculoskeletal Med, Oxford OX1 2JD, England

来源：

JOURNAL OF RHEUMATOLOGY | 2008年 / 35卷 / 08期

关键词：

ankylosing spondylitis; genetic studies; immune system;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS). Methods. A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed. Results. In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses. Conclusion. CD14 and TLR4 showed an association with AS in the Firms only.

引用

页码：1609 / 1612

页数：4

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