Molecular Scaffolds Using Multiple Orthogonal Conjugations: Applications in Chemical Biology and Drug Discovery

被引：91

作者：

Beal, David M. ^{[2
]}

Jones, Lyn H. ^{[1
,3
,4
]}

机构：

[1] Pfizer, Chem Biol, BioTherapeut Chem, WorldWide Med Chem, Cambridge, MA USA

[2] Univ Kent, Sci Biosci, Canterbury CT2 7NJ, Kent, England

[3] Pfizer, Orphan Dis Chem Grp, Cambridge, MA USA

[4] Pfizer, Genet Dis Chem Grp, Cambridge, MA USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 26期

关键词：

bioconjugation; chemical biology; click chemistry; molecular scaffolds; SOLID-PHASE; CLICK; CHEMISTRY; LIGATION;

D O I：

10.1002/anie.201200002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Heteromultifunctional scaffolds that harness sequential "click" reactions will find significant utility in the areas of chemical biology and chemically enabled/enhanced biotherapeutics ("chemologics"). Here we review the existing synthetic technologies that illustrate the considerable potential of the field. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6320 / 6326

页数：7

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