Biotransformation of sophoricoside in Fructus sophorae by the fungus Schizophyllum commune

被引：20

作者：

Wu, Jianguo ^{[1
]}

Yang, Xialu ^{[1
]}

Ge, Juan ^{[1
]}

Zhang, Yiping ^{[1
]}

Wu, Lin ^{[1
]}

Liu, Jianmiao ^{[1
]}

Zhang, Xiaoyu ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Minist Educ, Key Lab Mol Biophys, Wuhan 430074, Peoples R China

来源：

BIORESOURCE TECHNOLOGY | 2012年 / 111卷

关键词：

Schizophyllum commune; Sophoricoside; Fructus sophorae; Biotransformation; 4; 7-dihydroxy-5-methoxyisoflavone; GENISTEIN; PRODUCTS; CULTURE;

D O I：

10.1016/j.biortech.2012.02.038

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Biotransformation of sophoricoside in Fructus sophorae was performed with Schizophyllum commune. Sophoricoside was firstly metabolized to 4',5,7-trihydroxyisoflavone (2), and then to 4',7-dihydroxy-5-methoxyisoflavone (3) and 5,7-dihydroxy-4'-methoxyisoflavone (4) as determined by NMR and MS analyzes. The content of compound (2) was increased by more than 30-fold, and compound (3) is a new product that showed good cytotoxic activity with an IC50 of 12.1 nmol/ml against MCF-7 cells. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：496 / 499

页数：4

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