Highly anti-selective asymmetric nitro-Mannich reactions catalyzed by bifunctional amine-thiourea-bearing multiple hydrogen-bonding donors

被引：146

作者：

Wang, Chun-Jiang ^{[1
]}

Dong, Xiu-Qin ^{[1
]}

Zhang, Zhi-Hai ^{[1
]}

Xue, Zhi-Yong ^{[1
]}

Teng, Huai-Long ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 27期

关键词：

D O I：

10.1021/ja803538x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly anti-selective and enantioselective nitro-Mannich reactions have been achieved for a broad spectrum of substrates catalyzed by chiral bifunctional multiple hydrogen-bonding-donor amine-thioureas. Multiple hydrogen-bonding donors play a significant role in accelerating reactions and improving yields, diastereoselectivities, and enantioselectivities.

引用

页码：8606 / +

页数：3

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