Targeted Nanoprobes Reveal Early Time Point Kinetics In Vivo by Time-Resolved MRI

被引：11

作者：

Bhirde, Ashwinkumar ^{[1
]}

Guo, Ning ^{[1
]}

Chen, Xiaoyuan ^{[1
]}

机构：

[1] NIBIB, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA

来源：

THERANOSTICS | 2011年 / 1卷

关键词：

Commentary; Superparamagnetic Nanoparticles; Integrin; Cyclic RGD Peptide; Dynamic MRI; INTEGRIN; NANOPARTICLES; TUMORS; RGD;

D O I：

10.7150/thno/v01p0274

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This commentary highlights the findings by Kessinger et al. (Theranostics 2011; 1: 263-275) that dynamic T-2*-weighted magnetic resonance imaging (MRI) of cyclic RGD peptide-encoded superparamagnetic polymeric micelle (SPPM) nanoparticles allows quantitative analysis of tumor integrin alpha v beta 3 expression, which can exclude the effect of blood volume and extravascular signal components and thus provide less biased tumor contrast and receptor specificity of probes.

引用

页码：274 / 276

页数：3

共 24 条

[1] A model for MRI contrast enhancement using T1 agents [J].

Ahrens, ET ;

Rothbächer, U ;

Jacobs, RE ;

Fraser, SE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (15) :8443-8448

[2] PET Imaging of Integrin αVβ3 Expression [J].

Beer, Ambros J. ;

Kessler, Horst ;

Wester, Hans-Juergen ;

Schwaiger, Markus .

THERANOSTICS, 2011, 1 :48-57

[3] Nanoparticles for cell labeling [J].

Bhirde, Ashwinkumar ;

Xie, Jin ;

Swierczewska, Maggie ;

Chen, Xiaoyuan .

NANOSCALE, 2011, 3 (01) :142-153

[4] Integrin Targeted Delivery of Chemotherapeutics [J].

Chen, Kai ;

Chen, Xiaoyuan .

THERANOSTICS, 2011, 1 :189-200

[5] Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting [J].

Chen, Kai ;

Xie, Jin ;

Xu, Hengyi ;

Behera, Deepak ;

Michalski, Mark H. ;

Biswal, Sandip ;

Wang, Andrew ;

Chen, Xiaoyuan .

BIOMATERIALS, 2009, 30 (36) :6912-6919

[6] Functional tumor imaging with dynamic contrast-enhanced magnetic resonance imaging [J].

Choyke, PL ;

Dwyer, AJ ;

Knopp, MV .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2003, 17 (05) :509-520

[7] Multifunctional nanoparticles as coupled contrast agents [J].

Jin, Yongdong ;

Jia, Congxian ;

Huang, Sheng-Wen ;

O'Donnell, Matthew ;

Gao, Xiaohu .

NATURE COMMUNICATIONS, 2010, 1

[8] In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes [J].

John, Renu ;

Rezaeipoor, Robabeh ;

Adie, Steven G. ;

Chaney, Eric J. ;

Oldenburg, Amy L. ;

Marjanovic, Marina ;

Haldar, Justin P. ;

Sutton, Bradley P. ;

Boppart, Stephen A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (18) :8085-8090

[9] Investigation of In Vivo Targeting Kinetics of αvβ3-Specific Superparamagnetic Nanoprobes by Time-Resolved MRI [J].

Kessinger, Chase W. ;

Togao, Osamu ;

Khemtong, Chalermchai ;

Huang, Gang ;

Takahashi, Masaya ;

Gao, Jinming .

THERANOSTICS, 2011, 1 :263-273

[10] PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD) - Conjugated radiolabeled iron oxide nanoparticles [J].

Lee, Ha-Young ;

Li, Zibo ;

Chen, Kai ;

Hsu, Andrew R. ;

Xu, Chenjie ;

Xie, Jin ;

Sun, Shouheng ;

Chen, Xiaoyuan .

JOURNAL OF NUCLEAR MEDICINE, 2008, 49 (08) :1371-1379

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