Resolution of pain and complete healing of mandibular osteoradionecrosis using pentoxifylline and tocopherol: a case report

被引：24
作者：
Kahenasa, Nora [1 ,2 ]
Sung, Eric C. [1 ,3 ]
Nabili, Vishad [1 ,4 ]
Kelly, Jim [1 ]
Garrett, Neal [1 ]
Nishimura, Ichiro [1 ]
机构：
[1] Univ Calif Los Angeles, Sch Dent, Weintraub Ctr Reconstruct Biotechnol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Sch Dent, Sect Oral & Maxillofacial Surg, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Sch Dent, Sect Hosp Dent, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Los Angeles, CA 90095 USA
来源：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2012年 / 113卷 / 04期
关键词：
HYPERBARIC-OXYGEN THERAPY; ORAL PENTOXIFYLLINE; TISSUE-INJURY; CANCER; MANAGEMENT; DISEASE; RECONSTRUCTION; SURGERY; TRIAL;
D O I：
10.1016/j.oooo.2011.10.014
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The radiation-induced fibroatrophic process (RIF) is a time-dependent adverse sequela to high-dose radiotherapy that can result in irreversible tissue death and bone exposure in the irradiated tissue. Osteoradionecrosis (ORN) is a late effect of RIF, described as bony exposure present for more than 3 months that can occur in 20% of patients irradiated for head and neck cancer. The intractable characteristics of ORN make both management and resolution of the disease process challenging, with 25% of cases recurring despite aggressive treatment with resection and reconstruction of the necrotic bone. In this article, we present a case of a 66-year-old man with unevoked ORN of the left posterior lingual mandibular cortex that was successfully treated and resolved with 6 months of pentoxifylline 400 mg twice a day and tocopherol 1000 IU every day. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:e18-e23)
引用
收藏
页码：E18 / E23
页数：6
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