Piperine: researchers discover new flavor in an ancient spice

被引：56

作者：

Szallasi, A ^{[1
]}

机构：

[1] Monmouth Med Ctr, Dept Pathol, Long Branch, NJ 07740 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 09期

关键词：

D O I：

10.1016/j.tips.2005.07.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Studies with animals that are deficient in the vanilloid (capsaicin) receptor TRPV1 have confirmed the pivotal role that TRPV1 has in the development of post-inflammatory hyperalgesia, and enhanced TRPV1 expression has been described in various human disorders. Natural products have provided several lead structures for the development of vanilloid ligands. A recent study shows that piperine, the irritant principle in black pepper, is more efficient than capsaicin in the desensitization of human TRPV1, which suggests that this pharmacological aspect of vanilloids can be dissociated from its potency. This finding raises the intriguing possibility that piperine can be used as a chemical template for the design of improved TRPV1 agonists.

引用

页码：437 / 439

页数：3

共 15 条

[1]

Bley K., 2004, EXPERT OPIN INV DRUG, V13, P1

[2] The vanilloid receptor: A molecular gateway to the pain pathway [J].

Caterina, MJ ;

Julius, D .

ANNUAL REVIEW OF NEUROSCIENCE, 2001, 24 :487-517

[3] Biochemical pharmacology of the vanilloid receptor TRPV1 - An update [J].

Cortright, DN ;

Szallasi, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (10) :1814-1819

[4] Endovanilloid signaling in pain [J].

Di Marzo, V ;

Blumberg, PM ;

Szallasi, A .

CURRENT OPINION IN NEUROBIOLOGY, 2002, 12 (04) :372-379

[5] Vanilloid receptor TRPV1: hot on the tongue and inflaming the colon [J].

Holzer, P .

NEUROGASTROENTEROLOGY AND MOTILITY, 2004, 16 (06) :697-699

[6]

Jancso N., 1960, B MILLARD FILLMORE H, V7, P53

[7] Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells [J].

Liu, L ;

Simon, SA .

JOURNAL OF NEUROPHYSIOLOGY, 1996, 76 (03) :1858-1869

[8] Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1) [J].

McNamara, FN ;

Randall, A ;

Gunthorpe, MJ .

BRITISH JOURNAL OF PHARMACOLOGY, 2005, 144 (06) :781-790

[9] Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity [J].

Morenilla-Palao, C ;

Planells-Cases, R ;

García-Sanz, N ;

Ferrer-Montiel, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (24) :25665-25672

[10] Piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme and not by down regulation of CYP1A1 gene expression in the rat hepatoma 5L cell line [J].

Reen, RK ;

Roesch, SF ;

Kiefer, F ;

Wiebel, FJ ;

Singh, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 218 (02) :562-569

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