Correlation between circulating miR-122 and prognosis of chronic HBV-related liver failure

被引：26

作者：

Wang, Wei Jing ^{[1
]}

Lai, Rong Tao ^{[1
]}

Lu, Jie ^{[1
]}

Xiang, Xiao Gang ^{[1
]}

Zhao, Gang De ^{[1
]}

Tang, Wei Liang ^{[1
]}

Cai, Wei ^{[1
]}

Wang, Hui ^{[1
]}

Zhou, Hui Juan ^{[1
]}

Xie, Qing ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Infect Dis, Room 403,Bldg 36,197 Ruijin Er Rd, Shanghai 200025, Peoples R China

来源：

JOURNAL OF DIGESTIVE DISEASES | 2016年 / 17卷 / 05期

基金：

中国国家自然科学基金;

关键词：

chronic hepatitis B; end-stage liver disease; liver failure; microRNAs; prothrombin activity; HEPATITIS-B; CLINICAL-SIGNIFICANCE; SERUM-LEVELS; MICRORNAS; EXPRESSION; INJURY;

D O I：

10.1111/1751-2980.12348

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

OBJECTIVE: To assess the correlation between circulating microRNA (miR)-122 level and the prognosis of chronic hepatitis B-related liver failure (CHBLF). METHODS: Serum miR-122 from CHBLF patients (n = 6) and healthy controls (n = 6) was quantified using an Exiqon locked nucleic acid microarray. Quantitative real-time polymerase chain reaction was utilized to determine serum miR-122 expression in 102 patients with different liver diseases [CHBLF (n = 58), acute hepatitis B (n = 10), chronic hepatitis B (n = 22) and hepatitis B-related cirrhosis (n = 12)] and 23 healthy controls. The correlations between miR-122 and disease stages based on prothrombin activity (PTA) and model for end-stage liver disease (MELD) scores were further analyzed. RESULTS: Microarray showed that miR-122 was significantly upregulated among 148 significantly modified miRNAs in CHBLF patients. Serum level of miR-122 in CHBLF patients was significantly upregulated at early stage based on PTA or stages I-II based on MELD score. Interestingly, there was a significant correlation between the MELD score and circulating miR-122 level in patients with an MELD score of < 30 (r = 0.521, P = 0.001). Moreover, serum level of miR-122 was significantly decreased at discharge compared with that at admission as shown in the same group of CHBLF patients (P < 0.05). CONCLUSIONS: Serum level of miR-122 is correlated with the severity of liver injury at an early stage. miR-122 may be a potential biomarker for both the diagnosis at an early stage of CHBLF and the prognosis for recovery.

引用

页码：334 / 339

页数：6

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