N-Methylative aziridine ring opening and asymmetric synthesis of MeBmt

被引：9

作者：

Kim, Yongeun ^{[1
,2
]}

Yoon, Doo-Ha ^{[1
,2
]}

Ha, Hyun-Joon ^{[1
,2
]}

Kang, Kyung Yeon ^{[3
]}

Lee, Won Koo ^{[3
]}

机构：

[1] Hankuk Univ Foreign Studies, Dept Chem, Yongin 449719, Kyunggi Do, South Korea

[2] Hankuk Univ Foreign Studies, Prot Res Ctr Bioind, Yongin 449719, Kyunggi Do, South Korea

[3] Sogang Univ, Dept Chem, Seoul 121742, South Korea

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 45期

基金：

新加坡国家研究基金会;

关键词：

MeBmt; Asymmetric synthesis; Aziridine; Ring opening; Crotylation; UNUSUAL AMINO-ACID; STEREOSELECTIVE-SYNTHESIS; FORMAL SYNTHESIS; CHIRAL GLYCINE; CYCLOSPORINE; ALDEHYDES; KETONES;

D O I：

10.1016/j.tetlet.2011.08.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric synthesis of MeBmt, an unusual amino acid constituent of cyclosporine A, was achieved from aziridine-(2R)-carboxaldehyde through highly stereoselective addition of (E)-crotylboronate and the subsequent N-methylative aziridine ring opening as key steps. (C) 2011 Elsevier Ltd. All rights reserved.

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页码：5918 / 5920

页数：3

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