[2] Hosp Cosme Argerich, Rheumatol Dept, Buenos Aires, DF, Argentina
来源:
OPEN ACCESS RHEUMATOLOGY-RESEARCH AND REVIEWS
|
2020年
/
12卷
关键词:
vitamin D;
supplementation;
falls;
bone mineral density;
D SUPPLEMENTATION;
DOUBLE-BLIND;
D DEFICIENCY;
CONTROLLED-TRIAL;
ELDERLY PERSONS;
OLDER-PEOPLE;
WOMEN;
MEN;
CHOLECALCIFEROL;
POPULATION;
D O I:
10.2147/OARRR.S252245
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Introduction: Currently, approximately more than one billion people around the world are considered to have deficient levels of vitamin D. International consensus recommends vitamin D supplementation to high-risk patients (advanced age, osteoporosis, liver failure, malabsorption syndromes, etc.) and those with levels below 30 ng/mL. There are several vitamin D formulations and dosages available, including megadoses. At the moment, there is no consensus on the definition of megadoses. The purpose of this review is to define what is a megadose and analyze its effectiveness in bone metabolism, risk of fractures and falls. Conclusion: The administration of doses higher than 100,000 IU of vitamin D is considered a megadose. It is evident that the use of megadoses increases serum concentrations of vitamin D; however, there has been no evidence of a decrease in the risk of falls, vertebral fractures or changes in bone mineral
机构:
Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Harvard Sch Publ Hlth, Boston, MA 02111 USA
Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Bone Metab Lab, Boston, MA 02111 USAUniv Zurich Hosp, Ctr Aging & Mobil, CH-8091 Zurich, Switzerland
机构:
Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Harvard Sch Publ Hlth, Boston, MA 02111 USA
Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Bone Metab Lab, Boston, MA 02111 USAUniv Zurich Hosp, Ctr Aging & Mobil, CH-8091 Zurich, Switzerland