Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures

被引:10
作者
Narvaez, Jemina [1 ]
Maldonado, Genessis [1 ]
Guerrero, Roberto [1 ]
Messina, Osvaldo Daniel [2 ]
Rios, Carlos [1 ]
机构
[1] Espiritu Santo Univ, Rheumatol Dept, Guayaquil, Ecuador
[2] Hosp Cosme Argerich, Rheumatol Dept, Buenos Aires, DF, Argentina
来源
OPEN ACCESS RHEUMATOLOGY-RESEARCH AND REVIEWS | 2020年 / 12卷
关键词
vitamin D; supplementation; falls; bone mineral density; D SUPPLEMENTATION; DOUBLE-BLIND; D DEFICIENCY; CONTROLLED-TRIAL; ELDERLY PERSONS; OLDER-PEOPLE; WOMEN; MEN; CHOLECALCIFEROL; POPULATION;
D O I
10.2147/OARRR.S252245
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Currently, approximately more than one billion people around the world are considered to have deficient levels of vitamin D. International consensus recommends vitamin D supplementation to high-risk patients (advanced age, osteoporosis, liver failure, malabsorption syndromes, etc.) and those with levels below 30 ng/mL. There are several vitamin D formulations and dosages available, including megadoses. At the moment, there is no consensus on the definition of megadoses. The purpose of this review is to define what is a megadose and analyze its effectiveness in bone metabolism, risk of fractures and falls. Conclusion: The administration of doses higher than 100,000 IU of vitamin D is considered a megadose. It is evident that the use of megadoses increases serum concentrations of vitamin D; however, there has been no evidence of a decrease in the risk of falls, vertebral fractures or changes in bone mineral
引用
收藏
页码:105 / 115
页数:11
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