Matrix remodeling during endochondral ossification

被引：342

作者：

Ortega, N ^{[1
]}

Behonick, DJ ^{[1
]}

Werb, Z ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

来源：

TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 02期

关键词：

D O I：

10.1016/j.tcb.2003.12.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endochondral ossification, the process by which most of the skeleton is formed, is a powerful system for studying various aspects of the biological response to degraded extracellular matrix (ECM). In addition, the dependence of endochondral ossification upon neovascularization and continuous ECM remodeling provides a good model for studying the role of the matrix metalloproteases (MMPs) not only as simple effectors of ECM degradation but also as regulators of active signal-inducers for the initiation of endochondral ossification. The daunting task of elucidating their specific role during endochondral ossification has been facilitated by the development of mice deficient for various members of this family. Here, we discuss the ECM and its remodeling as one level of molecular regulation for the process of endochondral ossification, with special attention to the MMPs.

引用

页码：86 / 93

页数：8

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