Copper-Catalyzed Cascade Amination Route to N-Aryl Benzimidazoquinazolinones

被引：27

作者：

Banerjee, Arpan ^{[1
]}

Subramanian, Parthasarathi ^{[1
]}

Kaliappan, Krishna P. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 21期

关键词：

C-H AMINATION; ONE-POT; BOND FORMATION; KINASE INHIBITORS; DERIVATIVES; ACTIVATION; EFFICIENT; HETEROARYL; AMIDATION; CLEAVAGE;

D O I：

10.1021/acs.joc.6b01287

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot Cu-catalyzed C-H functionalization/two-fold C-N bond formation protocol for the syntheses of N-aryl benzimidazoquinazolinones is being reported. This strategy involves a Cu-catalyzed C-N bond coupling reaction between N-anilinoquinazolinones and aryl/heteroaryl halides followed by acetate ligand-assisted intramolecular C-H amination.(1a) This reaction is high-yielding and straightforward for the synthesis of anti-cancer drug analogues of benzimidazoquinazolinones.

引用

页码：10424 / 10432

页数：9

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