Geographical differences in survival of dogs with non-Hodgkin lymphoma treated with a CHOP based chemotherapy protocol

被引：12

作者：

Wilson-Robles, H. ^{[1
]}

Budke, C. M. ^{[2
]}

Miller, T. ^{[1
]}

Dervisis, N. ^{[3
]}

Novosad, A. ^{[4
]}

Wright, Z. ^{[5
]}

Thamm, D. H. ^{[6
]}

Vickery, K. ^{[7
]}

Burgess, K. ^{[8
]}

Childress, M. ^{[9
]}

Lori, J. ^{[10
]}

Saba, C. ^{[11
]}

Rau, S. ^{[12
]}

Silver, M. ^{[13
]}

Post, G. ^{[14
]}

Reeds, K. ^{[15
]}

Gillings, S. ^{[16
]}

Schleis, S. ^{[17
]}

Stein, T. ^{[18
]}

Brugmann, B. ^{[19
]}

DeRegis, C. ^{[20
]}

Smrkovski, O. ^{[21
]}

Lawrence, J. ^{[11
]}

Laver, T. ^{[22
]}

机构：

[1] Texas A&M Univ, Coll Vet Med, Small Anim Clin Sci Dept, 400 Raymond Stotzer Pkwy, College Stn, TX 77845 USA

[2] Texas A&M Univ, Coll Vet Med, Vet Integrat Biosci Dept, College Stn, TX 77843 USA

[3] Michigan State Univ, Dept Small Anim Clin Sci, Ctr Vet Med, E Lansing, MI 48824 USA

[4] Sugar Land Vet Specialists & Emergency Care, Sugar Land, TX USA

[5] VCA Anim Diagnost Clin, Dallas, TX USA

[6] Colorado State Univ, Coll Vet Med, Dept Clin Sci, Ft Collins, CO 80523 USA

[7] Hope Vet Specialists, Malvern, PA USA

[8] Tufts Univ, Dept Clin Sci, Cummings Sch Vet Med, North Grafton, MA USA

[9] Purdue Univ, Dept Vet Clin Sci, Coll Vet Med, W Lafayette, IN 47907 USA

[10] Anim Emergency & Specialty Ctr, Parker, CO USA

[11] Univ Minnesota, Coll Vet Med, Dept Vet Clin Sci, St Paul, MN 55108 USA

[12] Metropolitan Vet Associates, Norristown, PA USA

[13] New England Vet Oncol Grp, Waltham, MA USA

[14] Vet Canc Ctr, Dept Oncol, Norwalk, CT USA

[15] Oklahoma State Univ, Ctr Vet Hlth Sci, Vet Clin Sci Dept, Stillwater, OK 74078 USA

[16] Summit Vet Referral Ctr, Tacoma, WA USA

[17] Auburn Univ, Coll Vet Med, Clin Sci Dept, Auburn, AL 36849 USA

[18] Univ Wisconsin Madison, Sch Vet Med, Dept Med Sci, Madison, WI USA

[19] Louisiana State Univ, Sch Vet Med, Dept Vet Clin Sci, Baton Rouge, LA 70803 USA

[20] Pieper Mem Vet Ctr, Middletown, CT USA

[21] Univ Tennessee, Small Anim Clin Sci Dept, Coll Vet Med, Knoxville, TN USA

[22] Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg, Athens, GA USA

来源：

VETERINARY AND COMPARATIVE ONCOLOGY | 2017年 / 15卷 / 04期

关键词：

canine; CHOP; geographical differences; location; lymphoma; CANINE MALIGNANT-LYMPHOMA; PROGNOSTIC-FACTORS; 2,4-DICHLOROPHENOXYACETIC ACID; MAINTENANCE THERAPY; MULTICENTRIC LYMPHOMA; CANCER SURVIVAL; ASSOCIATION; TOXICITY; RISK; PROLIFERATION;

D O I：

10.1111/vco.12302

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Background: In humans geographical differences in the incidence and presentation of various cancers have been reported. However, much of this information has not been collected in veterinary oncology. Aims: The purpose of this study was to determine if a geographic difference in progression free survival exists for dogs with lymphoma treated within the US. Materials and Methods: Medical records of 775 cases of canine lymphoma from 3 US regions (west, south and north), treated with CHOP chemotherapy, were retrospectively evaluated. Cases were collected from referral institutions and were required to have received at least one doxorubicin treatment and have follow up information regarding time to progression. Results: Significant differences in sex (p = 0.05), weight (p = 0.049), stage (p < 0.001), immunophenotype (p = <0.001), and number of doxorubicin doses (p = 0.001) were seen between regions. Upon univariate analysis, progression free survival (PFS) differed by region (p = 0.006), stage (p = 0.009), sub-stage (p = 0.0005), and immunophenotype (p = 0.001). A multivariable Cox regression model showed that dogs in the western region had a significantly shorter PFS when compared to the south and east. Conclusions: PFS was significantly affected by stage, sub-stage and phenotype.

引用

页码：1564 / 1571

页数：8

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