Lipoic acid supplementation associated with neural epidermal growth factor-like 1 (NELL1)-associated membranous nephropathy

被引：40

作者：

Spain, Rebecca I. ^{[1
]}

Andeen, Nicole K. ^{[2
]}

Gibson, Pamela C. ^{[3
]}

Samuels, Mary H. ^{[4
]}

Morris, Cynthia D. ^{[4
]}

Solomon, Andrew J. ^{[5
]}

Solomon, Richard ^{[6
]}

Waslo, Carin ^{[7
]}

Avasare, Rupali S. ^{[8
]}

机构：

[1] Portland VA Med Ctr, Div Neurol, Portland, OR USA

[2] Oregon Hlth & Sci Univ, Dept Pathol & Lab Med, Portland, OR 97201 USA

[3] Univ Vermont, Dept Pathol & Larboratory Med, Robert Larner MD Coll Med, Burlington, VT USA

[4] Oregon Hlth & Sci Univ, Oregon Clin & Translat Res Inst, Portland, OR 97201 USA

[5] Univ Vermont, Dept Neurol Sci, Robert Larner MD Coll Med, Burlington, VT USA

[6] Univ Vermont, Div Nephrol & Hypertens, Robert Larner MD Coll Med, Burlington, VT USA

[7] Portland VA Med Ctr, Div Res, Portland, OR USA

[8] Oregon Hlth & Sci Univ, Div Nephrol & Hypertens, Dept Med, Portland, OR USA

来源：

KIDNEY INTERNATIONAL | 2021年 / 100卷 / 06期

基金：

美国国家卫生研究院;

关键词：

albuminuria; glomerulonephritis; kidney biopsy; kidney pathology; lipoic acid; membranous nephropathy; nephrotic syndrome; proteinuria; ANTI-PLA(2)R AUTOANTIBODIES; SPONTANEOUS REMISSION;

D O I：

10.1016/j.kint.2021.10.010

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Lipoic acid (alpha lipoic acid, thioctic acid) is a popular over-the-counter antioxidant and insulin-mimetic supplement under investigation in a variety of conditions including multiple sclerosis, diabetes, and schizophrenia. Unfortunately, high-grade proteinuria was an unexpected adverse event specific to the treatment arm of our clinical trial investigating lipoic acid supplementation in patients with multiple sclerosis. This observation led to detection of similar patients in our nephrology practice. Here, we describe four biopsy-proven cases of neural epidermal growth factor-like 1 (NELL1)-associated membranous nephropathy following lipoic acid supplementation and a fifth suspected case. Discontinuation of lipoic acid and supportive therapy resulted in remission.

引用

页码：1208 / 1213

页数：6

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