From Two to One Per Day Calibration of Dexcom G4 Platinum by a Time-Varying Day-Specific Bayesian Prior

Background: In the DexCom G4 Platinum (DG4P) continuous glucose monitoring (CGM) sensor, the raw current signal generated by glucose-oxidase is transformed to glucose concentration by a calibration function whose parameters are periodically updated by matching self-monitoring of blood glucose references, usually twice a day, to compensate for sensor variability in time. The aim of this work is to reduce DG4P calibration frequency to once a day by a recently proposed Bayesian calibration algorithm, which employs a time-varying calibration function and suitable day-specific priors. Methods: The database consists of 57 CGM signals that are collected by the DG4P for 7 days. The Bayesian calibration algorithm is used to calibrate the raw current signal following two different schedules, that is, two and one calibration per day. Calibrated glycemic profiles are compared with those originally acquired by the manufacturer, on days 1, 4, and 7, where frequent blood glucose references were available, by using standard metrics, that is, mean absolute relative difference (MARD), percentage of accurate glucose estimates, and percentage of data in the A-zone of Clarke Error Grid. Results: The one per day Bayesian calibration algorithm has accuracy similar to that of two per day (11.8% vs. 11.7% MARD, respectively), and it is statistically better (P-value of 0.0411) than the manufacturer calibration algorithm, which requires two calibrations per day (13.1% MARD). Conclusions: A Bayesian calibration algorithm employing a time-varying calibration function and suitable priors enables a reduction of the calibrations of DG4P sensor from two to one per day.