High-sensitivity laser confocal tomography based on frequency-shifted feedback technique

被引:9
作者
Zhou, Borui [1 ,2 ]
Wang, Zihan [1 ,2 ]
Shen, Xueju [2 ]
Zhang, Li [3 ]
Tan, Yidong [1 ]
机构
[1] Tsinghua Univ, State Key Lab Precis Measurement Technol & Instru, Beijing 100084, Peoples R China
[2] Army Engn Univ PLA, Dept Elect & Opt Engn, Shijiazhuang 050051, Hebei, Peoples R China
[3] Beijing Forestry Univ, Coll Sci, Beijing 100083, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Laser confocal tomography; Optical measurement; High sensitivity; Frequency-shifted feedback; Biological specimens imaging;
D O I
10.1016/j.optlaseng.2020.106059
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Laser confocal tomography faces severe challenges in weak signal detection such as biological tissue imaging and low-reflection interfaces measurement. An ultra-high sensitive optical confocal tomography based on laser frequency-shifted feedback imaging technology is presented, whose theoretical magnification can reach 10(6) notably without using high-gain detectors. In addition, this achievement possesses the same tomographic resolution as conventional laser confocal tomography without the need for spatial filtering devices. In this work, supported by theories and experiments, the lateral and vertical resolution, optical sensitivity, and system repeatability of LFCT and traditional LCT are investigated and analyzed quantificationally. Finally, comparison on the results of measuring the microfluidic device and biological tissue sections is conducted.
引用
收藏
页数:10
相关论文
共 34 条
[1]   Pulsed near-infrared laser diode excitation system for biomedical photoacoustic imaging [J].
Allen, Thomas J. ;
Beard, Paul C. .
OPTICS LETTERS, 2006, 31 (23) :3462-3464
[2]  
[Anonymous], VIRTUAL BIOPSIES HAN
[3]  
[Anonymous], ARCETRI FIRENZE
[4]   Classification of Limbal Stem Cell Deficiency Using Clinical and Confocal Grading [J].
Aravena, Carolina ;
Bozkurt, Kansu ;
Chuephanich, Pichaya ;
Supiyaphun, Chantaka ;
Yu, Fei ;
Deng, Sophie X. .
CORNEA, 2019, 38 (01) :1-7
[5]   Micro Electromechanical Systems (MEMS) Based Microfluidic Devices for Biomedical Applications [J].
Ashraf, Muhammad Waseem ;
Tayyaba, Shahzadi ;
Afzulpurkar, Nitin .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2011, 12 (06) :3648-3704
[6]   Phase sensitive optical near-field mapping using frequency-shifted laser optical feedback interferometry [J].
Blaize, Sylvain ;
Berenguier, Baptiste ;
Stefanon, Ilan ;
Bruyant, Aurelien ;
Lerondel, Gilles ;
Royer, Pascal ;
Hugon, Olivier ;
Jacquin, Olivier ;
Lacot, Eric .
OPTICS EXPRESS, 2008, 16 (16) :11718-11726
[7]   Confocal microscopy as a new real-time quantification method for oil content in produced water [J].
Fan, Jingjing ;
Sappington, Emily N. ;
Rifai, Hanadi S. ;
Rodrigues, Debora F. .
JOURNAL OF PETROLEUM SCIENCE AND ENGINEERING, 2018, 167 :54-63
[8]   Laser micromachining for microfluidic, microelectronic and MEMS applications [J].
Fedosejevs, R ;
Argument, M ;
Sardarli, A ;
Kirkwood, SE ;
Holenstein, R ;
Tsui, YY .
INTERNATIONAL CONFERENCE ON MEMS, NANO AND SMART SYSTEMS, PROCEEDINGS, 2003, :53-53
[9]   Imaging blood flow inside highly scattering media using ultrasound modulated optical tomography [J].
Hussain, Altaf ;
Steenbergen, Wiendelt ;
Vellekoop, Ivo M. .
JOURNAL OF BIOPHOTONICS, 2018, 11 (01)
[10]   Photoacoustic imaging platforms for multimodal imaging [J].
Kim, Jeesu ;
Lee, Donghyun ;
Jung, Unsang ;
Kim, Chulhong .
ULTRASONOGRAPHY, 2015, 34 (02) :88-97